Evidence map›Paper›PMID 29892285›Full record

ReviewFrontiers in immunology2018

Mechanisms of Fish Macrophage Antimicrobial Immunity.

Leon Grayfer, Baris Kerimoglu, Amulya Yaparla, Jordan W Hodgkinson, Jiasong Xie, Miodrag Belosevic

Abstract readReview
In one paragraph

Review in Frontiers in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed.

  1. Article
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  7. Amphibian (Journal of fungi (Basel, Switzerland) · 2025
    Article
  8. Article
  9. Article
  10. Article
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  12. Infection of endemic chubParasitology · 2024
    Article
  13. Article
  14. Article
  15. Differential Expression Genes of the Head Kidney and Spleen inInternational journal of molecular sciences · 2023
    Article
  16. Article
  17. Review
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Leon GrayferDepartment of Biological Sciences, George Washington University, Washington, DC, United States.
Baris KerimogluDepartment of Biological Sciences, George Washington University, Washington, DC, United States.
Amulya YaparlaDepartment of Biological Sciences, George Washington University, Washington, DC, United States.
Jordan W HodgkinsonDepartment of Biological Sciences, University of Alberta, Edmonton, AB, Canada.
Jiasong XieDepartment of Biological Sciences, University of Alberta, Edmonton, AB, Canada.
Miodrag BelosevicDepartment of Biological Sciences, University of Alberta, Edmonton, AB, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Overcrowding conditions and temperatures shifts regularly manifest in large-scale infections of farmed fish, resulting in economic losses for the global aquaculture industries. Increased understanding of the functional mechanisms of fish antimicrobial host defenses is an important step forward in prevention of pathogen-induced morbidity and mortality in aquaculture setting. Like other vertebrates, macrophage-lineage cells are integral to fish immune responses and for this reason, much of the recent fish immunology research has focused on fish macrophage biology. These studies have revealed notable similarities as well as striking differences in the molecular strategies by which fish and higher vertebrates control their respective macrophage polarization and functionality. In this review, we address the current understanding of the biological mechanisms of teleost macrophage functional heterogeneity and immunity, focusing on the key cytokine regulators that control fish macrophage development and their antimicrobial armamentarium.

Indexed as

ImmunityAdaptive ImmunityAnimalsBiomarkersDisease ResistanceFishesGene Expression RegulationHost-Pathogen InteractionsImmunity, InnateMacrophage ActivationMacrophagesSignal TransductionBiomarkersantimicrobialcytokinemacrophagesmonocytenitric oxidenutrient depravationrespiratory burstteleost

Identifiers

PMID29892285
PMCPMC5985312

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.