Evidence map›Paper›PMID 29892267›Full record

ArticleFrontiers in endocrinology2018

Ovarian Hormones Regulate the Production of Adipocytes From Bone Marrow-Derived Cells.

Kathleen M Gavin, Timothy M Sullivan, Wendy M Kohrt, Susan M Majka, Dwight J Klemm

Open access · goldAbstract read
In one paragraph

Article in Frontiers in endocrinology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Water Extract ofNutrients · 2020
    Article
  17. Sex Differences in Adipose Tissue Function.Endocrinology and metabolism clinics of North America · 2020
    Review
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 1 country.

Kathleen M GavinDivision of Geriatric Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Timothy M SullivanGeriatric Research, Education and Clinical Center, VA Eastern Colorado Heath Care System, Denver, CO, United States.
Wendy M KohrtDivision of Geriatric Medicine, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
Susan M MajkaDivision of Allergy, Pulmonary, and Critical Care Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN, United States.
Dwight J KlemmCharles C. Gates Center for Regenerative Medicine and Stem Cell Biology, School of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, United States.
VA Eastern Colorado Health Care System · USGeriatric Research Education and Clinical Center · USUniversity of Colorado Anschutz Medical Campus · USVanderbilt University · US

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
PILOT STUDY--SUBSTRATE METABOLISM IN EXTREMELY LOW BIRTH WEIGHT INFANTSP30DK048520 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI Edward L Melanson · 1995 to 2026
$32.6M
Suppression of ERalpha in Hematopoietic Stem Cell-Derived Adipocytes Increases Adiposity via Kynurenine and the Aryl Hydrocarbon ReceptorU54AG062319 · NIA · UNIVERSITY OF COLORADO DENVER · PI Paul S. Maclean · 2018 to 2026
$13.5M
Sex Hormones Differentially Regulate Production of Distinct Adipocyte PopulationP50HD073063 · NICHD · UNIVERSITY OF COLORADO DENVER · PI KOHRT, WENDY M · 2012 to 2017
$5.7M
A Novel Adipocyte Population Arises From Bone Marrow Progenitor CellsR01DK078966 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI KLEMM, DWIGHT J · 2008 to 2016
$2.6M
Integrin signaling promotes production of adipocytes from hematopoietic cellsR01DK109547 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI KLEMM, DWIGHT J · 2016 to 2019
$1.4M
Sex differences in adipogenic potential of adipose tissue myeloid cells in humansK01DK109053 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI GAVIN, KATHLEEN MARIE · 2016 to 2020
$724k
NCI NIH HHS P30 CA046934NIA NIH HHS U54 AG062319NICHD NIH HHS P50 HD073063NIDDK NIH HHS K01 DK109053NIDDK NIH HHS R01 DK078966NIDDK NIH HHS R01 DK109547
6 · The paper itself

Abstract

Sex differences in body fat distribution and menopause-associated shifts in regional adiposity suggest that sex hormones play an important role in regulating the differentiation and distribution of adipocytes, but the underlying mechanisms have not been fully explained. The aim of this study was to determine whether ovarian hormone status influences the production and distribution of adipocytes in adipose tissue arising from bone marrow-derived cells. Nine- to ten-week-old ovariectomized (OVX), surgery naïve (WT), and estrogen receptor alpha knockout (αERKO) mice underwent bone marrow transplantation from luciferase or green fluorescent protein expressing donors. A subset of OVX animals had estradiol (E

Indexed as

adipocytebone marrow-derived cellsbone marrow transplantestrogen receptormyeloid cellsovarian hormones

Identifiers

PMID29892267
PMCPMC5985395
OpenAlexW2806334900

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.