ArticleFrontiers in neurology2018
Modeling the Triggering of Saccades, Microsaccades, and Saccadic Intrusions.
Article in Frontiers in neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Microsaccade Activity During Visuospatial Working Memory in Early-Stage Parkinson's Disease.Journal of eye movement research · 2025Article
- Eyes on hold: motion task difficulty jointly delays microsaccade and pupil responses.Scientific reports · 2025Article
- Fixational saccade inhibition and pupil dilation during self-paced limb movement preparation.PloS one · 2025Article
- Opsoclonus Induced by Head-Shaking in Vestibular Migraine.Cerebellum (London, England) · 2024Article
- Spatial and Temporal Abnormalities of Spontaneous Fixational Saccades and Their Correlates With Positive and Cognitive Symptoms in Schizophrenia.Schizophrenia bulletin · 2024Article
- Oculomotor Dysfunction in Idiopathic and LRRK2-Parkinson's Disease and At-Risk Individuals.Journal of Parkinson's disease · 2024Article
- Patterns of small involuntary fixation saccades (SIFSs) in different neurodegenerative diseases: the role of noise.Experimental brain research · 2023Article
- Objective assessment of eye alignment and disparity-driven vergence in Parkinson's disease.Frontiers in aging neuroscience · 2023Article
- Eye tracking: empirical foundations for a minimal reporting guideline.Behavior research methods · 2023Review
- From anticipation to impulsivity in Parkinson's disease.NPJ Parkinson's disease · 2022Article
- The unknown but knowable relationship between Presaccadic Accumulation of activity and Saccade initiation.Journal of computational neuroscience · 2021Article
- Torsional component of microsaccades during fixation and quick phases during optokinetic stimulation.Journal of eye movement research · 2020Article
- Evidence for Attentional Phenotypes in Infancy and Their Role in Visual Cognitive Performance.Brain sciences · 2020Article
- Oculomotor freezing reflects tactile temporal expectation and aids tactile perception.Nature communications · 2020Article
- Microsaccades in Applied Environments: Real-World Applications of Fixational Eye Movement Measurements.Journal of eye movement research · 2020Article
- Directing Voluntary Temporal Attention Increases Fixational Stability.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Temporal Preparation, Impulsivity and Short-Term Memory in Depression.Frontiers in behavioral neuroscience · 2019Article
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Authors and funding
4 authors.
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Abstract
When we explore a static visual scene, our eyes move in a sequence of fast eye movements called saccades, which are separated by fixation periods of relative eye stability. Based on uncertain sensory and cognitive inputs, the oculomotor system must decide, at every moment, whether to initiate a saccade or to remain in the fixation state. Even when we attempt to maintain our gaze on a small spot, small saccades, called microsaccades, intrude on fixation once or twice per second. Because microsaccades occur at the boundary of the decision to maintain fixation versus starting a saccade, they offer a unique opportunity to study the mechanisms that control saccadic triggering. Abnormal saccadic intrusions can occur during attempted fixation in patients with neurodegenerative disorders. We have implemented a model of the triggering mechanism of saccades, based on known anatomy and physiology, that successfully simulates the generation of saccades of any size-including microsaccades in healthy observers, and the saccadic intrusions that interrupt attempted fixation in parkinsonian patients. The model suggests that noisy neuronal activity in the superior colliculus controls the state of a mutually inhibitory network in the brain stem formed by burst neurons and omnipause neurons. When the neuronal activity is centered at the rostral pole, the system remains at a state of fixation. When activity is perturbed away from this center, a saccade is triggered. This perturbation can be produced either by the intent to move one's gaze or by random fluctuations in activity.
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