ArticleFrontiers in physiology2018
Towards a Computational Framework for Modeling the Impact of Aortic Coarctations Upon Left Ventricular Load.
Article in Frontiers in physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Effect of the Mitral Valve on the Intra Ventricular Hemodynamics.International journal for numerical methods in biomedical engineering · 2026Article
- An efficient end-to-end computational framework for the generation of ECG calibrated volumetric models of human atrial electrophysiology.Medical image analysis · 2026Article
- A computational model of coronary arteries with in-stent restenosis coupling hemodynamics and pharmacokinetics with growth mechanics.Scientific reports · 2025Article
- Article
- Accurate Reconstruction of Right Heart Shape and Motion From Cine-MRI for Image-Driven Computational Hemodynamics.International journal for numerical methods in biomedical engineering · 2025Article
- Multiscale structure and function of the aortic valve apparatus.Physiological reviews · 2024Review
- Turbulent blood dynamics in the left heart in the presence of mitral regurgitation: a computational study based on multi-series cine-MRI.Biomechanics and modeling in mechanobiology · 2023Article
- A comprehensive mathematical model for cardiac perfusion.Scientific reports · 2023Article
- Global Sensitivity Analysis of Four Chamber Heart Hemodynamics Using Surrogate Models.IEEE transactions on bio-medical engineering · 2022Article
- Robust and efficient fixed-point algorithm for the inverse elastostatic problem to identify myocardial passive material parameters and the unloaded reference configuration.Journal of computational physics · 2022Article
- An accurate, robust, and efficient finite element framework with applications to anisotropic, nearly and fully incompressible elasticity.Computer methods in applied mechanics and engineering · 2022Article
- CT-Based Simulation of Left Ventricular Hemodynamics: A Pilot Study in Mitral Regurgitation and Left Ventricle Aneurysm Patients.Frontiers in cardiovascular medicine · 2022Article
- A coupling strategy for a first 3D-1D model of the cardiovascular system to study the effects of pulse wave propagation on cardiac function.Computational mechanics · 2022Article
- Predictive Model for Thrombus Formation After Transcatheter Valve Replacement.Cardiovascular engineering and technology · 2021Article
- A computationally efficient physiologically comprehensive 3D-0D closed-loop model of the heart and circulation.Computer methods in applied mechanics and engineering · 2021Article
- Image-Based Computational Hemodynamics Analysis of Systolic Obstruction in Hypertrophic Cardiomyopathy.Frontiers in physiology · 2021Article
- Versatile stabilized finite element formulations for nearly and fully incompressible solid mechanics.Computational mechanics · 2020Article
- Impact of Aortic Stenosis on Myofiber Stress: Translational Application of Left Ventricle-Aortic Coupling Simulation.Frontiers in physiology · 2020Article
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Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Computational fluid dynamics (CFD) models of blood flow in the left ventricle (LV) and aorta are important tools for analyzing the mechanistic links between myocardial deformation and flow patterns. Typically, the use of image-based kinematic CFD models prevails in applications such as predicting the acute response to interventions which alter LV afterload conditions. However, such models are limited in their ability to analyze any impacts upon LV load or key biomarkers known to be implicated in driving remodeling processes as LV function is not accounted for in a mechanistic sense. This study addresses these limitations by reporting on progress made toward a novel electro-mechano-fluidic (EMF) model that represents the entire physics of LV electromechanics (EM) based on first principles. A biophysically detailed finite element (FE) model of LV EM was coupled with a FE-based CFD solver for moving domains using an arbitrary Eulerian-Lagrangian (ALE) formulation. Two clinical cases of patients suffering from aortic coarctations (CoA) were built and parameterized based on clinical data under pre-treatment conditions. For one patient case simulations under post-treatment conditions after geometric repair of CoA by a virtual stenting procedure were compared against pre-treatment results. Numerical stability of the approach was demonstrated by analyzing mesh quality and solver performance under the significantly large deformations of the LV blood pool. Further, computational tractability and compatibility with clinical time scales were investigated by performing strong scaling benchmarks up to 1536 compute cores. The overall cost of the entire workflow for building, fitting and executing EMF simulations was comparable to those reported for image-based kinematic models, suggesting that EMF models show potential of evolving into a viable clinical research tool.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.