ReviewMolecular psychiatry2019
Brain age and other bodily 'ages': implications for neuropsychiatry.
Review in Molecular psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 256 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
256 citing papers in PubMed, 7 syntheses or guidelines pooled it, 470 citations in OpenAlex.
- Brain Aging in Specific Phobia: An ENIGMA-Anxiety Mega-Analysis.Human brain mapping · 2026Pooled it
- Meta-analysis of epigenetic aging in schizophrenia reveals multifaceted relationships with age, sex, illness duration, and polygenic risk.Clinical epigenetics · 2024Pooled it
- BrainAGE, brain health, and mental disorders: A systematic review.Neuroscience and biobehavioral reviews · 2024Pooled it
- Defining exceptional cognition in older adults: A systematic review of cognitive super-ageing.International journal of geriatric psychiatry · 2023Pooled it
- Brain ageing in schizophrenia: evidence from 26 international cohorts via the ENIGMA Schizophrenia consortium.Molecular psychiatry · 2023Pooled it
- The older adult brain is less modular, more integrated, and less efficient at rest: A systematic review of large-scale resting-state functional brain networks in aging.Psychophysiology · 2023Pooled it
- Factors associated with brain ageing - a systematic review.BMC neurology · 2021Pooled it
- Ultrasound Neuromodulation With Transcranial Pulse Stimulation in Alzheimer Disease: A Randomized Clinical Trial.JAMA network open · 2025Trial
- Predictive values of pre-treatment brain age models to rTMS effects in neurocognitive disorder with depression: Secondary analysis of a randomised sham-controlled clinical trial.Dialogues in clinical neuroscience · 2024Trial
- Improvement in the Prediction of Cerebrovascular Events With White Matter Hyperintensity.Journal of the American Heart Association · 2023Trial
- Your brain doesn't look a day past 70! Cross-sectional associations with brain-predicted age in the cognitively-intact oldest-old.GeroScience · 2026Article
- Sex-specific biological aging clocks across organs and omics.Nature medicine · 2026Article
- The Transdiagnostic Association Between Childhood Trauma and Accelerated Brain Aging in Two Independent Datasets.Schizophrenia bulletin · 2026Article
- Neonatal brain-age models in full- and preterm infants.Developmental cognitive neuroscience · 2026Article
- Exploring the link between body physiology and cognition: the role of the brain and aging.npj aging · 2026Article
- Brain Ageing in Social Anxiety Disorder: An ENIGMA-Anxiety Mega-Analysis Across 26 International Cohorts.medRxiv : the preprint server for health sciences · 2026Article
- Metabolic syndrome is associated with accelerated brain aging.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Age-related changes in behavioural and neural variability in a decision-making task.Nature communications · 2026Article
- Accelerated Brain Aging in Young Women with Posttraumatic Stress Disorder.Experimental neurobiology · 2026Article
- Metabolomic signatures of brain aging: A multimodal and genetic study.Molecular psychiatry · 2026Article
196 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
As our brains age, we tend to experience cognitive decline and are at greater risk of neurodegenerative disease and dementia. Symptoms of chronic neuropsychiatric diseases are also exacerbated during ageing. However, the ageing process does not affect people uniformly; nor, in fact, does the ageing process appear to be uniform even within an individual. Here, we outline recent neuroimaging research into brain ageing and the use of other bodily ageing biomarkers, including telomere length, the epigenetic clock, and grip strength. Some of these techniques, using statistical approaches, have the ability to predict chronological age in healthy people. Moreover, they are now being applied to neurological and psychiatric disease groups to provide insights into how these diseases interact with the ageing process and to deliver individualised predictions about future brain and body health. We discuss the importance of integrating different types of biological measurements, from both the brain and the rest of the body, to build more comprehensive models of the biological ageing process. Finally, we propose seven steps for the field of brain-ageing research to take in coming years. This will help us reach the long-term goal of developing clinically applicable statistical models of biological processes to measure, track and predict brain and body health in ageing and disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.