Evidence map›Paper›PMID 29892050›Full record

SynthesisNature communications2018

Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants.

Tokhir Dadaev, Edward J Saunders, Paul J Newcombe, Ezequiel Anokian, Daniel A Leongamornlert, Mark N Brook, Clara Cieza-Borrella, Martina Mijuskovic, Sarah Wakerell, Ali Amin Al Olama and 181 more

Registry-linked trialAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01221168 (ProGene), which is not on this map. Cited by 81 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
81citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01221168 recruitingnot on this map

ProGene: Etude Genetique et Epidemiologique du Cancer de la Prostate Familial

TypeobservationalSponsorCentre de Recherche sur les Pathologies ProstatiquesRan1996 to 2026Enrolled10,000ConditionsProstate Cancer
3 · Its place in the literature

Who cites it

81 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Can polygenic risk scores contribute to cost-effective cancer screening? A systematic review.Genetics in medicine : official journal of the American College of Medical Genetics · 2022
    Pooled it
  4. Pooled it
  5. Trial
  6. Trial
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  8. Review
  9. Article
  10. Review
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  17. A Haplotype GWAS in Syndromic Familial Colorectal Cancer.International journal of molecular sciences · 2025
    Article
  18. Article
  19. Article
  20. Article

21 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

191 authors.

Tokhir DadaevThe Institute of Cancer Research, London, SW7 3RP, UK.ORCID http://orcid.org/0000-0002-8268-0438
Edward J SaundersThe Institute of Cancer Research, London, SW7 3RP, UK.
Paul J NewcombeMRC Biostatistics Unit, University of Cambridge, Robinson Way, Cambridge, CB2 0SR, UK.
Ezequiel AnokianThe Institute of Cancer Research, London, SW7 3RP, UK.
Daniel A LeongamornlertThe Institute of Cancer Research, London, SW7 3RP, UK.ORCID http://orcid.org/0000-0002-3486-3168
Mark N BrookThe Institute of Cancer Research, London, SW7 3RP, UK.ORCID http://orcid.org/0000-0002-8969-2378
Clara Cieza-BorrellaThe Institute of Cancer Research, London, SW7 3RP, UK.
Martina MijuskovicThe Institute of Cancer Research, London, SW7 3RP, UK.
Sarah WakerellThe Institute of Cancer Research, London, SW7 3RP, UK.
Ali Amin Al OlamaCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge, CB1 8RN, UK.ORCID http://orcid.org/0000-0002-7178-3431
Fredrick R SchumacherDepartment of Population and Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, 44106-7219, USA.ORCID http://orcid.org/0000-0002-3073-7463
Sonja I BerndtDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, 20892, USA.
Sara BenllochThe Institute of Cancer Research, London, SW7 3RP, UK.
Mahbubl AhmedThe Institute of Cancer Research, London, SW7 3RP, UK.
Chee GohThe Institute of Cancer Research, London, SW7 3RP, UK.
Xin ShengDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, 90015, USA.
Zhuo ZhangDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, 90015, USA.
Kenneth MuirInstitute of Population Health, University of Manchester, Manchester, M13 9PL, UK.ORCID http://orcid.org/0000-0001-6429-988X
Koveela GovindasamiThe Institute of Cancer Research, London, SW7 3RP, UK.
Artitaya LophatananonInstitute of Population Health, University of Manchester, Manchester, M13 9PL, UK.
Victoria L StevensEpidemiology Research Program, American Cancer Society, 250 Williams Street, Atlanta, GA, 30303, USA.
Susan M GapsturEpidemiology Research Program, American Cancer Society, 250 Williams Street, Atlanta, GA, 30303, USA.
Brian D CarterEpidemiology Research Program, American Cancer Society, 250 Williams Street, Atlanta, GA, 30303, USA.
Catherine M TangenSWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.
Phyllis GoodmanSWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.
Ian M ThompsonCHRISTUS Santa Rosa Hospital - Medical Center, San Antonio, TX, 78229, USA.
Jyotsna BatraAustralian Prostate Cancer Research Centre-Qld, Institute of Health and Biomedical Innovation and School of Biomedical Science, Queensland University of Technology, Brisbane, QLD, 4059, Australia.ORCID http://orcid.org/0000-0003-4646-6247
Suzanne ChambersMenzies Health Institute Queensland, Griffith University, Gold Coast, QLD, 4222, Australia.
Leire MoyaAustralian Prostate Cancer Research Centre-Qld, Institute of Health and Biomedical Innovation and School of Biomedical Science, Queensland University of Technology, Brisbane, QLD, 4059, Australia.
Judith ClementsAustralian Prostate Cancer Research Centre-Qld, Institute of Health and Biomedical Innovation and School of Biomedical Science, Queensland University of Technology, Brisbane, QLD, 4059, Australia.
Lisa HorvathChris O'Brien Lifehouse (COBLH), Camperdown, Sydney, NSW, 2010, Australia.
Wayne TilleyDame Roma Mitchell Cancer Research Centre, University of Adelaide, Adelaide, SA, 5005, Australia.
Gail RisbridgerDepartment of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Monash University, Melbourne, VIC, 3800, Australia.
Henrik GronbergDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, SE-171 77, Stockholm, Sweden.
Markus AlyDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, SE-171 77, Stockholm, Sweden.
Tobias NordströmDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, SE-171 77, Stockholm, Sweden.ORCID http://orcid.org/0000-0003-4915-7546
Paul PharoahCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge, CB1 8RN, UK.ORCID http://orcid.org/0000-0001-8494-732X
Nora PashayanCentre for Cancer Genetic Epidemiology, Department of Oncology, Strangeways Laboratory, University of Cambridge, Cambridge, CB1 8RN, UK.ORCID http://orcid.org/0000-0003-0843-2468
Johanna SchleutkerInstitute of Biomedicine, University of Turku, FI-20014, Turku, Finland.ORCID http://orcid.org/0000-0002-1863-0305
Teuvo L J TammelaDepartment of Urology, Tampere University Hospital, University of Tampere, Kalevantie 4, FI-33014, Tampere, Finland.
Csilla SipekyInstitute of Biomedicine, University of Turku, FI-20014, Turku, Finland.ORCID http://orcid.org/0000-0002-8853-4722
Anssi AuvinenDepartment of Epidemiology, School of Health Sciences, University of Tampere, FI-33014, Tampere, Finland.
Demetrius AlbanesDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, 20892, USA.
Stephanie WeinsteinDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, 20892, USA.
Alicja WolkDivision of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, SE-171 77, Stockholm, Sweden.ORCID http://orcid.org/0000-0001-7387-6845
Niclas HakanssonDivision of Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, SE-171 77, Stockholm, Sweden.
Catharine WestDivision of Cancer Sciences, Manchester Academic Health Science Centre, Radiotherapy Related Research, Manchester NIHR Biomedical Research Centre, The Christie Hospital NHS Foundation Trust, University of Manchester, Manchester, M13 9PL, UK.
Alison M DunningCentre for Cancer Genetic Epidemiology, Department of Oncology, Strangeways Laboratory, University of Cambridge, Cambridge, CB1 8RN, UK.
Neil BurnetUniversity of Cambridge Department of Oncology, Oncology Centre, Cambridge University Hospitals NHS Foundation Trust, Cambridge, CB1 8RN, UK.
Lorelei MucciDepartment of Epidemiology, Harvard School of Public Health, Boston, MA, 02115, USA.
Edward GiovannucciDepartment of Epidemiology, Harvard School of Public Health, Boston, MA, 02115, USA.
Gerald AndrioleWashington University School of Medicine, St. Louis, MO, 63110, USA.
Olivier CussenotGRC N°5 ONCOTYPE-URO, UPMC Univ Paris 06, Tenon Hospital, F-75020, Paris, France.
Géraldine Cancel-TassinGRC N°5 ONCOTYPE-URO, UPMC Univ Paris 06, Tenon Hospital, F-75020, Paris, France.ORCID http://orcid.org/0000-0002-9583-6382
Stella KoutrosDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, 20892, USA.
Laura E Beane FreemanDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, 20892, USA.
Karina Dalsgaard SorensenDepartment of Molecular Medicine, Aarhus University Hospital, 8200, Aarhus N, Denmark.ORCID http://orcid.org/0000-0002-4902-5490
Torben Falck OrntoftDepartment of Molecular Medicine, Aarhus University Hospital, 8200, Aarhus N, Denmark.
Michael BorreDepartment of Clinical Medicine, Aarhus University, 8200, Aarhus N, Denmark.
Lovise MaehleDepartment of Medical Genetics, Oslo University Hospital, 0424, Oslo, Norway.
Eli Marie GrindedalDepartment of Medical Genetics, Oslo University Hospital, 0424, Oslo, Norway.
David E NealDepartment of Oncology, Addenbrooke's Hospital, University of Cambridge, Cambridge, CB2 0QQ, UK.
Jenny L DonovanSchool of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol, BS8 2PS, UK.
Freddie C HamdyNuffield Department of Surgical Sciences, University of Oxford, Oxford, OX1 2JD, UK.
Richard M MartinSchool of Social and Community Medicine, University of Bristol, Canynge Hall, 39 Whatley Road, Bristol, BS8 2PS, UK.
Ruth C TravisCancer Epidemiology, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.
Tim J KeyCancer Epidemiology, Nuffield Department of Population Health, University of Oxford, Oxford, OX3 7LF, UK.
Robert J HamiltonDepartment of Surgical Oncology, Princess Margaret Cancer Centre, Toronto, ON, M5G 2M9, Canada.
Neil E FleshnerDepartment of Surgical Oncology, Princess Margaret Cancer Centre, Toronto, ON, M5G 2M9, Canada.
Antonio FinelliDepartment of Surgical Oncology, Princess Margaret Cancer Centre, Toronto, ON, M5G 2M9, Canada.
Sue Ann InglesDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, 90015, USA.
Mariana C SternDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, 90015, USA.
Barry RosensteinDepartment of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA.
Sarah KernsDepartment of Radiation Oncology, University of Rochester Medical Center, Rochester, NY, 14620, USA.ORCID http://orcid.org/0000-0002-6503-0011
Harry OstrerProfessor of Pathology and Pediatrics, Albert Einstein College of Medicine, Bronx, NY, 10461, USA.ORCID http://orcid.org/0000-0002-2209-5376
Yong-Jie LuCentre for Molecular Oncology, Barts Cancer Institute, John Vane Science Centre, Queen Mary University of London, London, EC1M 6BQ, UK.
Hong-Wei ZhangSecond Military Medical University, Shanghai, 200433, P. R. China.
Ninghan FengWuxi Second Hospital, Nanjing Medical University, Wuxi, Jiangzhu, 214003, China.
Xueying MaoCentre for Molecular Oncology, Barts Cancer Institute, John Vane Science Centre, Queen Mary University of London, London, EC1M 6BQ, UK.
Xin GuoDepartment of Urology, The First Affiliated Hospital, Chongqing Medical University, Chongqing, 200032, China.
Guomin WangDepartment of Urology, Zhongshan Hospital, Fudan University Medical College, Shanghai, 200032, China.
Zan SunThe People's Hospital of Liaoning Province and The People's Hospital of China Medical University, Shenyang, 110001, China.
Graham G GilesCancer Epidemiology & Intelligence Division, Cancer Council Victoria, Melbourne, VIC, 3004, Australia.
Melissa C SoutheyPrecision Medicine, School and Clinical Sciences at Monash Health, Monash University, Clayton, VIC, 3168, Australia.
Robert J MacInnisCancer Epidemiology & Intelligence Division, Cancer Council Victoria, Melbourne, VIC, 3004, Australia.
Liesel M FitzGeraldCentre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, 3010, Australia.
Adam S KibelDivision of Urologic Surgery, Brigham and Womens Hospital, Boston, MA, 02115, USA.
Bettina F DrakeWashington University School of Medicine, St. Louis, MO, 63110, USA.
Ana VegaFundación Pública Galega de Medicina Xenómica-SERGAS, Grupo de Medicina Xenómica, CIBERER, IDIS, Santiago de Compostela, 15706, Spain.
Antonio Gómez-CaamañoDepartment of Radiation Oncology, Complexo Hospitalario Universitario de Santiago, SERGAS, 15706, Santiago de Compostela, Spain.
Laura FachalCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge, CB1 8RN, UK.ORCID http://orcid.org/0000-0002-7256-9752
Robert SzulkinDivision of Family Medicine, Department of Neurobiology, Care Science and Society, Karolinska Institutet, Huddinge, SE-171 77, Stockholm, Sweden.
Martin EklundDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, SE-171 77, Stockholm, Sweden.
Manolis KogevinasCentre for Research in Environmental Epidemiology (CREAL), Barcelona Institute for Global Health (ISGlobal), 08003, Barcelona, Spain.ORCID http://orcid.org/0000-0002-9605-0461
Javier LlorcaCIBER Epidemiología y Salud Pública (CIBERESP), 28029, Madrid, Spain.
Gemma Castaño-VinyalsCentre for Research in Environmental Epidemiology (CREAL), Barcelona Institute for Global Health (ISGlobal), 08003, Barcelona, Spain.
Kathryn L PenneyChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital/Harvard Medical School, Boston, MA, 02184, USA.
Meir StampferChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital/Harvard Medical School, Boston, MA, 02184, USA.
Jong Y ParkDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, 33612, USA.
Thomas A SellersDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, 33612, USA.
Hui-Yi LinSchool of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA, 70112, USA.
Janet L StanfordDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109-1024, USA.
Cezary CybulskiInternational Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, 70-115, Szczecin, Poland.
Dominika WokolorczykInternational Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, 70-115, Szczecin, Poland.
Jan LubinskiInternational Hereditary Cancer Center, Department of Genetics and Pathology, Pomeranian Medical University, 70-115, Szczecin, Poland.
Elaine A OstranderNational Human Genome Research Institute, National Institutes of Health, Bethesda, MD, 20892, USA.
Milan S GeybelsDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109-1024, USA.
Børge G NordestgaardFaculty of Health and Medical Sciences, University of Copenhagen, 2200, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-1954-7220
Sune F NielsenFaculty of Health and Medical Sciences, University of Copenhagen, 2200, Copenhagen, Denmark.
Maren WeisherDepartment of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, 2200, Copenhagen, Denmark.
Rasmus BisbjergDepartment of Urology, Herlev and Gentofte Hospital, Copenhagen University Hospital, Herlev, 2200, Copenhagen, Denmark.
Martin Andreas RøderCopenhagen Prostate Cancer Center, Department of Urology, Rigshospitalet, Copenhagen University Hospital, DK-2730, Herlev, Denmark.
Peter IversenFaculty of Health and Medical Sciences, University of Copenhagen, 2200, Copenhagen, Denmark.
Hermann BrennerDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), D-69120, Heidelberg, Germany.
Katarina CukDivision of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), D-69120, Heidelberg, Germany.
Bernd HolleczekSaarland Cancer Registry, 66119, Saarbrücken, Germany.
Christiane MaierInstitute for Human Genetics, University Hospital Ulm, 89075, Ulm, Germany.
Manuel LuedekeInstitute for Human Genetics, University Hospital Ulm, 89075, Ulm, Germany.
Thomas SchnoellerDepartment of Urology, University Hospital Ulm, 89075, Ulm, Germany.
Jeri KimDepartment of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Christopher J LogothetisDepartment of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Esther M JohnCancer Prevention Institute of California, Fremont, CA, 94538, USA.
Manuel R TeixeiraDepartment of Genetics, Portuguese Oncology Institute of Porto, 4200-072, Porto, Portugal.
Paula PauloDepartment of Genetics, Portuguese Oncology Institute of Porto, 4200-072, Porto, Portugal.
Marta CardosoDepartment of Genetics, Portuguese Oncology Institute of Porto, 4200-072, Porto, Portugal.
Susan L NeuhausenDepartment of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA, 91010, USA.
Linda SteeleDepartment of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA, 91010, USA.
Yuan Chun DingDepartment of Population Sciences, Beckman Research Institute of the City of Hope, Duarte, CA, 91010, USA.
Kim De RuyckGhent University, Faculty of Medicine and Health Sciences, Basic Medical Sciences, B-9000, Gent, Belgium.
Gert De MeerleerGhent University, Faculty of Medicine and Health Sciences, Basic Medical Sciences, B-9000, Gent, Belgium.
Piet OstDepartment of Radiotherapy, Ghent University Hospital, B-9000, Gent, Belgium.
Azad RazackDepartment of Surgery, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.
Jasmine LimDepartment of Surgery, Faculty of Medicine, University of Malaya, 50603, Kuala Lumpur, Malaysia.ORCID http://orcid.org/0000-0002-7501-1834
Soo-Hwang TeoCancer Research Malaysia (CRM), Outpatient Centre, Subang Jaya Medical Centre, 47500, Subang Jaya, Selangor, Malaysia.
Daniel W LinDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109-1024, USA.
Lisa F NewcombDivision of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109-1024, USA.
Davor LesselInstitute of Human Genetics, University Medical Center Hamburg-Eppendorf, D-20246, Hamburg, Germany.
Marija GamulinDivision of Medical Oncology, Urogenital Unit, Department of Oncology at the University Hospital Centre Zagreb, Šalata 2, 10000, Zagreb, Croatia.
Tomislav KulisDepartment of Urology, University Hospital Center Zagreb, University of Zagreb School of Medicine, Šalata 2, 10000, Zagreb, Croatia.
Radka KanevaMolecular Medicine Center, Department of Medical Chemistry and Biochemistry, Medical University of Sofia, 1431, Sofia, Bulgaria.
Nawaid UsmaniDepartment of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, AB, T6G 1Z2, Canada.
Chavdar SlavovDepartment of Urology and Alexandrovska University Hospital, Medical University of Sofia, 1431, Sofia, Bulgaria.
Vanio MitevMolecular Medicine Center, Department of Medical Chemistry and Biochemistry, Medical University of Sofia, 1431, Sofia, Bulgaria.
Matthew ParliamentDepartment of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, AB, T6G 1Z2, Canada.
Sandeep SinghalDepartment of Oncology, Cross Cancer Institute, University of Alberta, Edmonton, AB, T6G 1Z2, Canada.
Frank ClaessensMolecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, BE-3000, Leuven, Belgium.
Steven JoniauDepartment of Urology, University Hospitals Leuven, BE-3000, Leuven, Belgium.
Thomas Van den BroeckMolecular Endocrinology Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, BE-3000, Leuven, Belgium.
Samantha LarkinSouthampton General Hospital, The University of Southampton, Southampton, SO16 6YD, UK.
Paul A TownsendManchester Cancer Research Centre, Faculty of Biology Medicine & Health, Manchester Academic Health Science Centre, NIHR Manchester Biomedical Research Centre, Health Innovation Manchester, University of Manchester, Manchester, M13 9WL, UK.
Claire Aukim-HastieThe University of Surrey, Guildford, Surrey, GU2 7XH, UK.
Manuela Gago-DominguezGenomic Medicine Group, Galician Foundation of Genomic Medicine, Instituto de Investigacion Sanitaria de Santiago de Compostela (IDIS), Complejo Hospitalario Universitario de Santiago, Servicio Galego de Saúde, SERGAS, 15706, Santiago de Compostela, Spain.
Jose Esteban CastelaoGenetic Oncology Unit, CHUVI Hospital, Complexo Hospitalario Universitario de Vigo, Instituto de Investigación Biomédica Galicia Sur (IISGS), 36204, Vigo (Pontevedra), Spain.
Maria Elena MartinezMoores Cancer Center, Department of Family Medicine and Public Health, University of California San Diego, La Jolla, CA, 92093-0012, USA.
Monique J RoobolDepartment of Urology, Erasmus University Medical Center, 3015 CE, Rotterdam, The Netherlands.
Guido JensterDepartment of Urology, Erasmus University Medical Center, 3015 CE, Rotterdam, The Netherlands.
Ron H N van SchaikDepartment of Clinical Chemistry, Erasmus University Medical Center, 3015 CE, Rotterdam, The Netherlands.
Florence MenegauxCancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, 94807, Villejuif Cédex, France.
Thérèse TruongCancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, 94807, Villejuif Cédex, France.ORCID http://orcid.org/0000-0002-2943-6786
Yves Akoli KoudouCancer & Environment Group, Center for Research in Epidemiology and Population Health (CESP), INSERM, University Paris-Sud, University Paris-Saclay, 94807, Villejuif Cédex, France.
Jianfeng XuProgram for Personalized Cancer Care, NorthShore University HealthSystem, Evanston, IL, 60201, USA.ORCID http://orcid.org/0000-0002-1343-8752
Kay-Tee KhawClinical Gerontology Unit, University of Cambridge, Cambridge, CB2 2QQ, UK.
Lisa Cannon-AlbrightDivision of Genetic Epidemiology, Department of Medicine, University of Utah School of Medicine, Salt Lake City, UT, 84112, USA.
Hardev PandhaThe University of Surrey, Guildford, Surrey, GU2 7XH, UK.
Agnieszka MichaelThe University of Surrey, Guildford, Surrey, GU2 7XH, UK.
Andrzej KierzekThe University of Surrey, Guildford, Surrey, GU2 7XH, UK.
Stephen N ThibodeauDepartment of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, 55905, USA.
Shannon K McDonnellDivision of Biomedical Statistics & Informatics, Mayo Clinic, Rochester, MN, 55905, USA.
Daniel J SchaidDivision of Biomedical Statistics & Informatics, Mayo Clinic, Rochester, MN, 55905, USA.
Sara LindstromDepartment of Epidemiology, University of Washington, Seattle, WA, 98195, USA.
Constance TurmanProgram in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.
Jing MaChanning Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital/Harvard Medical School, Boston, MA, 02184, USA.
David J HunterProgram in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.
Elio RiboliDepartment of Epidemiology and Biostatistics, School of Public Health, Imperial College, London, SW7 2AZ, UK.
Afshan SiddiqGenomics England, Queen Mary University of London, Dawson Hall, Charterhouse Square, London, EC1M 6BQ, UK.
Federico CanzianGenomic Epidemiology Group, German Cancer Research Center (DKFZ), D-69120, Heidelberg, Germany.
Laurence N KolonelEpidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, 96813, USA.
Loic Le MarchandEpidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, 96813, USA.
Robert N HooverDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, 20892, USA.
Mitchell J MachielaDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, 20892, USA.
Peter KraftProgram in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, 02115, USA.
PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium
Matthew FreedmanDana-Farber Cancer Institute, Boston, MA, 02215, USA.
Fredrik WiklundDepartment of Medical Epidemiology and Biostatistics, Karolinska Institute, SE-171 77, Stockholm, Sweden.
Stephen ChanockDivision of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, MD, 20892, USA.
Brian E HendersonDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, 90015, USA.
Douglas F EastonCentre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge, Cambridge, CB1 8RN, UK.ORCID http://orcid.org/0000-0003-2444-3247
Christopher A HaimanDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, 90015, USA.
Rosalind A EelesThe Institute of Cancer Research, London, SW7 3RP, UK.ORCID http://orcid.org/0000-0002-3698-6241
David V ContiDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California/Norris Comprehensive Cancer Center, Los Angeles, CA, 90015, USA.
Zsofia Kote-JaraiThe Institute of Cancer Research, London, SW7 3RP, UK. zsofia.kote-jarai@icr.ac.uk.

Funding

SWOG Foreign AccrualsU10CA037429 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI BLANKE, CHARLES D., MEYSKENS, FRANK L. · 1985 to 2014
$205.2M
SWOG NCORP Research BaseUG1CA189974 · NCI · THE HOPE FOUNDATION · PI CHARLES D. BLANKE, DAWN HERSHMAN · 2014 to 2026
$80.6M
Finding Genes for Human Prostate CancerZIAHG200325 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI OSTRANDER, ELAINE · 2009 to 2021
$17.7M
PCPT and SELECT cohorts: Core Infrastructure Support for Cancer Research UM1CA182883 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI TANGEN, CATHERINE M., THOMPSON, IAN M. · 2013 to 2017
$5.2M
Risk Prediction for Development of Adverse Effects FOllowing Radiotherapy for Prostate CancerK07CA187546 · NCI · UNIVERSITY OF ROCHESTER · PI KERNS, SARAH L. · 2015 to 2019
$649k
Cancer Research UK 13232Cancer Research UK 14136Cancer Research UK 15007Cancer Research UK 16491Cancer Research UK 16565Cancer Research UK 17528Cancer Research UK 18504Cancer Research UK 19170Cancer Research UK 21332Medical Research Council G0401527Medical Research Council G1000143Medical Research Council MC_UU_00002/9Medical Research Council MR/N003284/1NCI NIH HHS K07 CA187546NCI NIH HHS U10 CA037429NCI NIH HHS UG1 CA189974NCI NIH HHS UM1 CA182883
6 · The paper itself

Abstract

Prostate cancer is a polygenic disease with a large heritable component. A number of common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here we apply the Bayesian multivariate variable selection algorithm JAM to fine-map 84 prostate cancer susceptibility loci, using summary data from a large European ancestry meta-analysis. We observe evidence for multiple independent signals at 12 regions and 99 risk signals overall. Only 15 original GWAS tag SNPs remain among the catalogue of candidate variants identified; the remainder are replaced by more likely candidates. Biological annotation of our credible set of variants indicates significant enrichment within promoter and enhancer elements, and transcription factor-binding sites, including AR, ERG and FOXA1. In 40 regions at least one variant is colocalised with an eQTL in prostate cancer tissue. The refined set of candidate variants substantially increase the proportion of familial relative risk explained by these known susceptibility regions, which highlights the importance of fine-mapping studies and has implications for clinical risk profiling.

Indexed as

AlgorithmsBayes TheoremBlack PeopleChromosome MappingGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansMaleMolecular Sequence AnnotationMultivariate AnalysisPolymorphism, Single NucleotideProstatic NeoplasmsQuantitative Trait LociRiskWhite People

Identifiers

PMID29892050
PMCPMC5995836

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.