ArticleScientific reports2018
Fibrinogen - A Practical and Cost Efficient Biomarker for Detecting Periprosthetic Joint Infection.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 26 papers, 3 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 52 citations in OpenAlex.
- Role of D-dimer and Fibrinogen in the Diagnosis of Periprosthetic Joint Infection: A Systematic Review and Meta-Analysis.Orthopaedic surgery · 2021Pooled it
- Reliability of circulating fibrinogen in the diagnosis of prosthesis-related infections: a systematic review and meta-analysis.Journal of orthopaedic surgery and research · 2021Pooled it
- Fibrinogen performs better than D-dimer for the diagnosis of periprosthetic joint infection: a meta-analysis of diagnostic trials.Journal of orthopaedic surgery and research · 2021Pooled it
- Plasma fibrinogen in the diagnosis of periprosthetic joint infection.Scientific reports · 2021Trial
- Clinical application of combined CRP and PCT detection in diagnosing and prognosing fracture-related infections.Frontiers in cellular and infection microbiology · 2025Article
- Analysis of Serum and Synovial Inflammatory Markers in Periprosthetic Joint Infections: A Narrative Review.Cureus · 2024Review
- The Low-Abundance Plasma Proteome Reveals Differentially Abundant Proteins Associated with Breast Implant Capsular Contracture: A Pilot Study.Proteomes · 2024Article
- Efficacy analysis of clinical serological indicators in the diagnosis of postoperative periprosthetic joint infection in patients with rheumatoid arthritis or osteoarthritis.International orthopaedics · 2024Article
- Diagnostic Values of Serum Inflammatory Biomarkers after Hip and Knee Arthroplasty in Patients with Periprosthetic Joint Infection.Healthcare (Basel, Switzerland) · 2024Article
- Diagnostics in Late Periprosthetic Infections-Challenges and Solutions.Antibiotics (Basel, Switzerland) · 2024Review
- To Evaluate the Efficacy of Biomarkers as Monitoring Tool in Patients with Fascial Space Infections of Odontogenic Origin: A Clinical Study.Journal of maxillofacial and oral surgery · 2024Article
- Can C-Reactive Protein-Lymphocyte Ratio Be Used as a Screening Tool to Confirm the Diagnosis of Periprosthetic Joint Infection?Clinics in orthopedic surgery · 2023Article
- Utility of D-dimer in total joint arthroplasty.World journal of orthopedics · 2023Review
- Complete blood platelet and lymphocyte ratios increase diagnostic accuracy of periprosthetic joint infection following total hip arthroplasty.Archives of orthopaedic and trauma surgery · 2023Article
- The Challenge of Periprosthetic Joint Infection Diagnosis: From Current Methods to Emerging Biomarkers.International journal of molecular sciences · 2023Review
- Serum procalcitonin has no significance in the diagnosis of periprosthesis joint infection before total hip and knee replacement.Frontiers in surgery · 2023Article
- Decreased serum superoxide dismutase concentration has a high value for the diagnosis of periprosthetic joint infection-a single-center, retrospective study.BMC musculoskeletal disorders · 2022Article
- A Platelet-Rich Plasma-Derived Biologic ClearsFrontiers in cellular and infection microbiology · 2022Article
- Serum Inflammatory Biomarkers in the Diagnosis of Periprosthetic Joint Infections.Biomedicines · 2021Review
- Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The early and accurate diagnosis of periprosthetic joint infection (PJI) can be challenging. Fibrinogen plays an important role in mediating inflammation of bacterial infections and therefore could be a valuable biomarker for PJI. The purpose of this study was to investigate the sensitivity and specificity of serum levels of fibrinogen in detecting PJI, and to compare the results with the established PJI biomarkers C-reactive protein (CRP) and leukocyte count. Eighty-four patients (124 surgeries) were prospectively included. The preoperatively analyzed parameters were fibrinogen, CRP and leukocyte count. The sensitivity and specificity of the biomarkers were calculated and compared. Fibrinogen (p < 0.001), CRP (p < 0.001) and leukocyte count (p < 0.001) had a statistically significant correlation with the criteria defining the presence of PJI. For fibrinogen, the value of 519 mg/dl had a sensitivity of 0.90 and a specificity of 0.34. The CRP cut-off point of 11.00 mg/dl had a sensitivity of 0.90 and a specificity of 0.74. The leukocyte count of 5.68 G/l had a sensitivity of 0.90 and a specificity of 0.39. Our results indicated that fibrinogen is a significant biomarker for detecting a bacterial PJI. It has shown to be a cost-efficient diagnostic support with high sensitivity and specificity.
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