ArticleInternational journal of obesity (2005)2018
Polygenic differential susceptibility to cumulative stress exposure and childhood obesity.
Article in International journal of obesity (2005), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 2 of them syntheses that pooled it.
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Who cites it
7 citing papers in PubMed, 2 syntheses or guidelines pooled it, 17 citations in OpenAlex.
- Cross-sectional relation of long-term glucocorticoids in hair with anthropometric measurements and their possible determinants: A systematic review and meta-analysis.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2022Pooled it
- Associations Between Different Cortisol Measures and Adiposity in Children: A Systematic Review and Meta-Analysis.Frontiers in nutrition · 2022Pooled it
- Polygenic Childhood Obesity: Integrating Genetics and Environment for Early Intervention.Hormone research in paediatrics · 2026Review
- Early and later susceptibility to effects of parenting: Exploring Frankenhuis and Panchanathan's (2011) evolutionary commitment hypothesis.Developmental psychology · 2025Article
- Risk factors and prediction for pediatric obesity: current status and future perspectives.Endocrine journal · 2025Review
- Synergizing Mouse and Human Studies to Understand the Heterogeneity of Obesity.Advances in nutrition (Bethesda, Md.) · 2021Review
- Temperament, socioeconomic adversity, and perinatal risk as related to preschoolers' BMI.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2021Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo examine whether polygenic susceptibility for body mass index (BMI) interacts with cumulative stress exposure, potentially exacerbating and buffering the effects of chronic stress, to predict obesity during childhood.
methodsData were analyzed from an established prospective puberty cohort in Anhui province, China. A total of 1000 children (421 boys and 579 girls, mean (standard deviation) age 8.97 (0.86) years) who had complete DNA genotyping, hair cortisol concentration and BMI were eligible for the study. The polygenic susceptibility score (PSS) was computed based on 11 SNPs derived from a published genome-wide association study for child obesity.
resultsChildren with different obesity polygenic susceptibility did not differ in BMI, obesogenic behaviors and HCC. The positive association between HCC with BMI was only found among children with highest PSS (r = 0.269, P < 0.001). When exposed in cumulative stress, children with highest PSS have higher BMI (β = 1.46, 95% CI: 0.63, 2.29; P = 0.001) than those having lowest PSS. The reverse pattern was found among children without cumulative stress exposure, those with highest PSS showed lowest BMI (β = -1.27, 95% CI: -2.17, -0.38; P = 0.001), compared to lowest PSS groups. Re-parameterized regression models provide strong support for the differential susceptibility hypothesis.
conclusionsThe findings underlie the importance of shifting perspectives from gene vulnerability to gene plasticity in the field of childhood obesity prevention. Children carrying additional BMI-raising alleles are at heightened risk of obesity are at heightened risk of obesity; however, they seem to be protected against obesity when the adverse psychosocial environment is removed.
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