ArticleNature communications2018
Interplay of the two ancient metabolites auxin and MEcPP regulates adaptive growth.
Article in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Sulfur metabolism-dependent retrograde signaling for oxidative stress acclimation.Journal of experimental botany · 2026Review
- Metabolite control of enzyme activity links stress to biosynthetic regulation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Plastids in a Pinch: Coordinating Stress and Developmental Responses Through Retrograde Signalling.Plant, cell & environment · 2025Review
- The methylerythritol phosphate pathway as an oxidative stress sense and response system.Nature communications · 2024Review
- Arabidopsis TGA256 Transcription Factors Suppress Salicylic-Acid-Induced Sucrose Starvation.Plants (Basel, Switzerland) · 2023Article
- Co-regulation of mitochondrial and chloroplast function: Molecular components and mechanisms.Plant communications · 2023Review
- Role of plastids and mitochondria in the early development of seedlings in dark growth conditions.Frontiers in plant science · 2023Review
- Aux/IAA11 Is Required for UV-AB Tolerance and Auxin Sensing in Arabidopsis thalianaInternational journal of molecular sciences · 2022Article
- A plastidial retrograde signal potentiates biosynthesis of systemic stress response activators.The New phytologist · 2022Article
- Arbuscular mycorrhiza mitigates zinc stress onFrontiers in plant science · 2022Article
- A Chloroplast-Derived Signal Attenuates Growth in Red Light by Acting on the phyB-PIF Pathway.Plant physiology · 2020Article
- Retrograde Induction of phyB Orchestrates Ethylene-Auxin Hierarchy to Regulate Growth.Plant physiology · 2020Article
- Linking mitochondrial and chloroplast retrograde signalling in plants.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Chloroplast-associated molecular patterns as concept for fine-tuned operational retrograde signalling.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- ThePhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Article
- Orthogonal regulation of phytochrome B abundance by stress-specific plastidial retrograde signaling metabolite.Nature communications · 2019Article
- ANAC017 Coordinates Organellar Functions and Stress Responses by Reprogramming Retrograde Signaling.Plant physiology · 2019Article
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Authors and funding
10 authors.
Funding
Abstract
The ancient morphoregulatory hormone auxin dynamically realigns dedicated cellular processes that shape plant growth under prevailing environmental conditions. However, the nature of the stress-responsive signal altering auxin homeostasis remains elusive. Here we establish that the evolutionarily conserved plastidial retrograde signaling metabolite methylerythritol cyclodiphosphate (MEcPP) controls adaptive growth by dual transcriptional and post-translational regulatory inputs that modulate auxin levels and distribution patterns in response to stress. We demonstrate that in vivo accumulation or exogenous application of MEcPP alters the expression of two auxin reporters, DR5:GFP and DII-VENUS, and reduces the abundance of the auxin-efflux carrier PIN-FORMED1 (PIN1) at the plasma membrane. However, pharmacological intervention with clathrin-mediated endocytosis blocks the PIN1 reduction. This study provides insight into the interplay between these two indispensable signaling metabolites by establishing the mode of MEcPP action in altering auxin homeostasis, and as such, positioning plastidial function as the primary driver of adaptive growth.
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