ArticleNature materials2018
Therapeutic luminal coating of the intestine.
Article in Nature materials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 70 citations in OpenAlex.
- Smart coacervate microdroplets: biomimetic design, material innovations, and emerging applications in biomacromolecule delivery.Bioactive materials · 2025Review
- Oral delivery of liquid mRNA therapeutics by an engineered capsule for treatment of preclinical intestinal disease.Science translational medicine · 2025Article
- Development of a targeted oral pharmacologic duodenal exclusion therapy for the treatment of metabolic diseases.Science advances · 2025Article
- Bioresponsive and transformable coacervate actuated by intestinal peristalsis for targeted treatment of intestinal bleeding and inflammation.Bioactive materials · 2024Article
- Novel strategies for modulating the gut microbiome for cancer therapy.Advanced drug delivery reviews · 2024Review
- Reinforcement of the intestinal mucosal barrier via mucus-penetrating PEGylated bacteria.Nature biomedical engineering · 2024Article
- The synthesis and evaluation of thiolated alginate as the barrier to block nutrient absorption on small intestine for body-weight control.Bioengineering & translational medicine · 2023Article
- A multifunctional integrated biomimetic spore nanoplatform for successively overcoming oral biological barriers.Journal of nanobiotechnology · 2023Article
- Nanomaterial-assisted CRISPR gene-engineering - A hallmark for triple-negative breast cancer therapeutics advancement.Materials today. Bio · 2022Review
- A single-cell nanocoating of probiotics for enhanced amelioration of antibiotic-associated diarrhea.Nature communications · 2022Article
- Daily transient coating of the intestine leads to weight loss and improved glucose tolerance.Metabolism: clinical and experimental · 2022Article
- Design Strategy for a Hydroxide-Triggered pH-Responsive Hydrogel as a Mucoadhesive Barrier to Prevent Metabolism Disorders.ACS applied materials & interfaces · 2021Article
- Nanoparticle-assembled bioadhesive coacervate coating with prolonged gastrointestinal retention for inflammatory bowel disease therapy.Nature communications · 2021Article
- Mimicking Native Display of CD0873 on Liposomes Augments Its Potency as an Oral Vaccine againstVaccines · 2021Article
- Colon-Targeted Adhesive Hydrogel Microsphere for Regulation of Gut Immunity and Flora.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2021Article
- Magnetic Living Hydrogels for Intestinal Localization, Retention, and Diagnosis.Advanced functional materials · 2021Article
- Orally administered saccharide-sequestering nanocomplex to manage carbohydrate metabolism disorders.Science advances · 2021Article
- An orally delivered microbial cocktail for the removal of nitrogenous metabolic waste in animal models of kidney failure.Nature biomedical engineering · 2020Article
- Gastrointestinal synthetic epithelial linings.Science translational medicine · 2020Article
- Synergistically Enhanced Mucoadhesive and Penetrable Polypeptide Nanogel for Efficient Drug Delivery to Orthotopic Bladder Cancer.Research (Washington, D.C.) · 2020Article
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The gastrointestinal tract is the site of most drug delivery and therapeutic interventions for the management and treatment of numerous diseases. However, selective access to its mucosa, especially in the small bowel, is challenging. Here we develop an orally administered gut-coating formulation that provides a transient coating of the bowel. Through a materials screening campaign, we identified a sucrose octasulfate aluminium complex and further engineered the pH-dependent material into a complex coacervate formulation linked via pH-independent electrostatic interaction, which allowed an effective transient physical coating on the gastrointestinal mucosa, independent of gastric acid exposure. We tested the therapeutic values of this technology in two settings. Oral administration of this gut-coating formulation modulated the nutrient contact with bowel mucosa, which lowered the glucose responses in rodent models indicating a potential therapeutic utility in diabetes. Furthermore, the formulation protected biological agents from gastric acid exposure and degradation, which enabled oral delivery to the small bowel mucosa.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.