ArticleEuropean journal of human genetics : EJHG2018
Trans-eQTLs identified in whole blood have limited influence on complex disease biology.
Article in European journal of human genetics : EJHG, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed, 5 citations in OpenAlex.
- An eQTL-based approach reveals candidate regulators of LINE-1 RNA levels in lymphoblastoid cells.PLoS genetics · 2024Article
- Methods and Insights from Single-Cell Expression Quantitative Trait Loci.Annual review of genomics and human genetics · 2023Review
- Imputed gene associations identify replicable trans-acting genes enriched in transcription pathways and complex traits.Genetic epidemiology · 2019Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
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Abstract
Trans-eQTLs have been implicated in complex traits and common diseases, but many were initially identified on the basis of having an effect in cis, and there has been no assessment of the significance of the overlap in relation to chance expectations. Here, we investigated whether trans-expression quantitative trait loci (eQTL) associations identified in whole blood contribute to variance in complex traits by determining (1) whether genome-wide significant (GWS) single-nucleotide polymorphisms (SNPs) were enriched for trans-eQTL (including trans-only eQTL), and (2) whether the genomic regions surrounding associated trans-genes were enriched for statistical associations in the relevant GWAS. On average for a given phenotype, we identify 4.8% of GWS SNPs overlapping with trans-eQTL present in blood, and show that for the majority of these phenotypes, this observation does not exceed that expected by chance. Likewise, we observe no enrichment for genetic associations with the GWAS phenotype in the regions surrounding the linked trans-genes, with the exception of rheumatoid arthritis. Interestingly, the GWS SNPs for each phenotype were consistently more enriched for unique trans-eQTL SNPs than trans-eQTL SNP-probe pairs (p = 4 × 10
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