Evidence map›Paper›PMID 29891860›Full record

ArticleScientific reports2018

Microsomal Prostaglandin E Synthase-1 Plays a Critical Role in Long-term Motility Dysfunction after Bowel Obstruction.

You-Min Lin, Yu Fu, Shrilakshmi Hegde, Yanbo Tang, Ravi Radhakrishnan, Xuan-Zheng Shi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 2 countries.

You-Min LinDepartment of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA.
Yu FuDepartment of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA.
Shrilakshmi HegdeDepartment of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA.
Yanbo TangDepartment of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA.
Ravi RadhakrishnanDepartment of Surgery, University of Texas Medical Branch, Galveston, TX, USA.
Xuan-Zheng ShiDepartment of Internal Medicine, University of Texas Medical Branch, Galveston, TX, USA. xushi@utmb.edu.
The University of Texas Medical Branch at Galveston · US

Funding

Pathogenesis of gut dysfunction in bowel obstruction and after obstruction is resolvedR01DK102811 · NIDDK · UNIVERSITY OF TEXAS MED BR GALVESTON · PI SHI, XUAN-ZHENG PETER · 2015 to 2018
$1.4M
NIDDK NIH HHS R01 DK102811
6 · The paper itself

Abstract

Motility dysfunction is present not only during bowel obstruction (BO), but after obstruction is resolved. Previous studies found that lumen distension associated mechano-transcription of COX-2 and production of PGE

Indexed as

Gastrointestinal MotilityAnimalsColonCyclooxygenase 2DinoprostoneDisease Models, AnimalGastrointestinal TransitIntestinal ObstructionMyocytes, Smooth MuscleProstaglandin-E SynthasesRatsCyclooxygenase 2DinoprostoneProstaglandin-E SynthasesPtges protein, ratPtgs2 protein, rat

Identifiers

PMID29891860
PMCPMC5995953
OpenAlexW2806772448

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.