ArticleScientific reports2018
Reminder duration determines threat memory modification in humans.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Navigating the garden of forking paths for data exclusions in fear conditioning research.eLife · 2019Pooled it
- Post-retrieval oxytocin facilitates next day extinction of threat memory in humans.Psychopharmacology · 2019Trial
- A ventral hippocampus-basolateral amygdala circuit regulates the unconditioned stimulus retrieval-induced reconsolidation of remote fear memory.Journal of advanced research · 2026Article
- Dissociable memory modulation mechanisms facilitate fear amnesia at different timescales.eLife · 2025Article
- The Impact of Continuous and Partial Reinforcement on the Acquisition and Generalization of Human-Conditioned Fear.Behavioral sciences (Basel, Switzerland) · 2024Article
- Neuromodulation and memory: exploring ethical ramifications in memory modification treatment via implantable neurotechnologies.Frontiers in psychology · 2023Article
- Active suppression prevents the return of threat memory in humans.Communications biology · 2021Article
- Neural Computations of Threat.Trends in cognitive sciences · 2021Review
- Investigating the efficacy of the reminder-extinction procedure to disrupt contextual threat memories in humans using immersive Virtual Reality.Scientific reports · 2020Article
- No persistent attenuation of fear memories in humans: A registered replication of the reactivation-extinction effect.Cortex; a journal devoted to the study of the nervous system and behavior · 2020Article
- Destabilizing Different Strengths of Fear Memories Requires Different Degrees of Prediction Error During Retrieval.Frontiers in behavioral neuroscience · 2020Article
- Postretrieval Relearning Strengthens Hippocampal Memories via Destabilization and Reconsolidation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
Corrections and comments
- Erratum issued
Authors and funding
6 authors.
Funding
Abstract
Memory reminders can return a memory into an unstable state such that it will decay unless actively restabilized into long-term memory through reconsolidation. Exposure to a memory reminder, however, does not always lead to destabilization. The 'trace dominance' principle posits that the extent of exposure to memory reminders governs memory susceptibility to disruption. Here, we provide a first systematic investigation of reminder duration effects on threat memory modification in humans. Reminder duration was parametrically varied across 155 participants in a three-day protocol. We found that short reminders (1 s and 4 s) made the memory prone to interference from post-retrieval extinction, suggesting that the memory had been updated. In contrast, no reminder or long reminders (30 s and 3 min) made the memory resistant to such interference, and robustly return. Reminder duration therefore influences memory stability and may be a critical determinant of therapeutic efficacy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.