Evidence map›Paper›PMID 29891806›Full record

ArticleInternational journal of molecular sciences2018

Anti-Atherogenic Effects of Vaspin on Human Aortic Smooth Muscle Cell/Macrophage Responses and Hyperlipidemic Mouse Plaque Phenotype.

Kengo Sato, Remina Shirai, Maho Yamaguchi, Tomoyuki Yamashita, Koichiro Shibata, Taisuke Okano, Yusaku Mori, Taka-Aki Matsuyama, Hatsue Ishibashi-Ueda, Tsutomu Hirano and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
3.4field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 34 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Adipokines in atherosclerosis: unraveling complex roles.Frontiers in cardiovascular medicine · 2023
    Review
  5. Article
  6. Adipokines, adiposity, and atherosclerosis.Cellular and molecular life sciences : CMLS · 2022
    Review
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. International journal of endocrinology · 2020
    Article
  16. The Adipokine Network in Rheumatic Joint Diseases.International journal of molecular sciences · 2019
    Review
  17. Legumain Promotes Atherosclerotic Vascular Remodeling.International journal of molecular sciences · 2019
    Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Kengo SatoLaboratory of Cardiovascular Medicine, Tokyo University of Pharmacy and Life Sciences, Tokyo 192-0392, Japan. ksato@toyaku.ac.jp.
Remina ShiraiLaboratory of Cardiovascular Medicine, Tokyo University of Pharmacy and Life Sciences, Tokyo 192-0392, Japan. s106101@toyaku.ac.jp.
Maho YamaguchiLaboratory of Cardiovascular Medicine, Tokyo University of Pharmacy and Life Sciences, Tokyo 192-0392, Japan. s139110@toyaku.ac.jp.
Tomoyuki YamashitaLaboratory of Cardiovascular Medicine, Tokyo University of Pharmacy and Life Sciences, Tokyo 192-0392, Japan. s126208@toyaku.ac.jp.
Koichiro ShibataLaboratory of Cardiovascular Medicine, Tokyo University of Pharmacy and Life Sciences, Tokyo 192-0392, Japan. s149064@toyaku.ac.jp.
Taisuke OkanoLaboratory of Cardiovascular Medicine, Tokyo University of Pharmacy and Life Sciences, Tokyo 192-0392, Japan. s149021@toyaku.ac.jp.
Yusaku MoriDepartment of Medicine, Division of Diabetes, Metabolism, and Endocrinology, Showa University School of Medicine, Tokyo 142-8666, Japan. torigoe1234@yahoo.co.jp.
Taka-Aki MatsuyamaDepartment of Legal Medicine, Showa University School of Medicine, Tokyo 142-8555, Japan. taka94242879@gmail.com.
Hatsue Ishibashi-UedaDepartment of Pathology, National Cerebral and Cardiovascular Center, Osaka 565-8565, Japan. hueda@ncvc.go.jp.ORCID 0000-0001-5153-9805
Tsutomu HiranoDepartment of Medicine, Division of Diabetes, Metabolism, and Endocrinology, Showa University School of Medicine, Tokyo 142-8666, Japan. hirano@med.showa-u.ac.jp.
Takuya WatanabeLaboratory of Cardiovascular Medicine, Tokyo University of Pharmacy and Life Sciences, Tokyo 192-0392, Japan. watanabe@toyaku.ac.jp.ORCID 0000-0001-9996-2063
Tokyo University of Pharmacy and Life Sciences · JPShowa University · JPNational Cerebral and Cardiovascular Center · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Vaspin (visceral adipose tissue-derived serine protease inhibitor) was recently identified as a novel adipocytokine with insulin-sensitizing effects. Serum vaspin levels are reported either increased or decreased in patients with coronary artery disease. Our translational research was performed to evaluate the expression of vaspin in human coronary atherosclerotic lesions, and its effects on atherogenic responses in human macrophages and human aortic smooth muscle cells (HASMC), as well as aortic atherosclerotic lesion development in spontaneously hyperlipidemic

Indexed as

AnimalsAortaApolipoproteins EApoptosisAtherosclerosisCell MovementCell ProliferationExtracellular MatrixFoam CellsHumansHyperlipidemiasInflammationMacrophagesMiceModels, BiologicalMyocytes, Smooth MuscleApolipoproteins ESERPINA12 protein, humanSerpinsApoe−/− miceatherosclerosismacrophagevascular smooth muscle cellvaspin

Identifiers

PMID29891806
PMCPMC6032338
OpenAlexW2805709638

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.