SynthesisInternational journal of molecular sciences2018
Cytotoxicity of Plant-Mediated Synthesis of Metallic Nanoparticles: A Systematic Review.
Synthesis in International journal of molecular sciences, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 98 citations in OpenAlex.
- Biosynthesis, characterization, and antiproliferative activity of gold nanoparticles synthesized using Artemisia chamaemelifolia extract against cisplatin-resistant ovarian cancer cells.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2026Article
- Green Synthesis Characterization and Evaluation ofMolecules (Basel, Switzerland) · 2026Article
- Metal Nanoparticles as Sensitizers in Energy-Based Therapies for Lung Cancer: From Mechanistic Insights to Clinical Translation.International journal of nanomedicine · 2026Review
- In vitro evaluation of cytotoxicity and release kinetics of green-synthesisedCytotechnology · 2025Article
- Transforming bone cancer treatment: a comprehensive review of green-synthesized metal nanoparticles.Cancer cell international · 2025Review
- Pharmacological Potential of Three Berberine-Containing Plant Extracts Obtained fromBiomedicines · 2024Article
- Harvesting the Power of Green Synthesis: Gold Nanoparticles Tailored for Prostate Cancer Therapy.International journal of molecular sciences · 2024Article
- Updates on Biogenic Metallic and Metal Oxide Nanoparticles: Therapy, Drug Delivery and Cytotoxicity.Pharmaceutics · 2023Review
- Biogeneration of silver nanoparticles from Cuphea procumbens for biomedical and environmental applications.Scientific reports · 2023Article
- In Vivo Evaluation of Anti-Nociceptive Effects of Silver Nanoparticles.Molecules (Basel, Switzerland) · 2022Article
- Antineoplastic activity of biogenic silver and gold nanoparticles to combat leukemia: Beginning a new era in cancer theragnostic.Biotechnology reports (Amsterdam, Netherlands) · 2022Article
- The Potential Application of Green-Synthesized Metal Nanoparticles in Dentistry: A Comprehensive Review.Bioinorganic chemistry and applications · 2022Review
- Biogenic Silver Nanoparticles Strategically Combined WithFrontiers in microbiology · 2022Article
- Gold Nanoparticles: Biosynthesis and Potential of Biomedical Application.Journal of functional biomaterials · 2021Review
- Mechanistic aspects of plant-based silver nanoparticles against multi-drug resistant bacteria.Heliyon · 2021Review
- Cytotoxicity of targeted PLGA nanoparticles: a systematic review.RSC advances · 2021Review
- Biogenic Silver Nanoparticles ofBioinorganic chemistry and applications · 2021Article
- A Review on Drug Delivery System for Tumor Therapy.Frontiers in pharmacology · 2021Review
- Wheat Germ Agglutinin-Conjugated Disulfide Cross-Linked Alginate Nanoparticles as a Docetaxel Carrier for Colon Cancer Therapy.International journal of nanomedicine · 2021Article
- Cytotoxicity and insulin resistance reversal ability of biofunctional phytosynthesized MgO nanoparticles.3 Biotech · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the field of medicine, nanomaterials, especially those derived using the green method, offer promise as anti-cancer agents and drug carriers. However, the biosafety of metallic nanoparticles used as anti-cancer agents remains a concern. The goal of this systematic review was to compare the cytotoxicity of different plant-mediated syntheses of metallic nanoparticles based on their potency, therapeutic index, and cancer cell type susceptibility in the hopes of identifying the most promising anti-cancer agents. A literature search of electronic databases including Science Direct, PubMed, Springer Link, Google Scholar, and ResearchGate, was conducted to obtain research articles. Keywords such as biosynthesis, plant synthesis, plant-mediated, metallic nanoparticle, cytotoxicity, and anticancer were used in the literature search. All types of research materials that met the inclusion criteria were included in the study regardless of whether the results were positive, negative, or null. The therapeutic index was used as a safety measure for the studied compound of interest. Data from 76 selected articles were extracted and synthesised. Seventy-two studies reported that the cytotoxicity of plant-mediated synthesis of metallic nanoparticles was time and/or dose-dependent. Biosynthesised silver nanoparticles demonstrated higher cytotoxicity potency compared to gold nanoparticles synthesised by the same plants (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.