Evidence map›Paper›PMID 29891656›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Direct activation of a phospholipase by cyclic GMP-AMP in El Tor

Geoffrey B Severin, Miriam S Ramliden, Lisa A Hawver, Kun Wang, Macy E Pell, Ann-Katrin Kieninger, Atul Khataokar, Brendan J O'Hara, Lara V Behrmann, Matthew B Neiditch and 3 more

Open access · greenAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.

0numbers the graph read from it
0cells of the map it votes in
87citing papers in PubMed
9.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

87 citing papers in PubMed, 137 citations in OpenAlex.

  1. Molecular control of bacterial immunity.Nature structural & molecular biology · 2026
    Review
  2. Article
  3. Review
  4. Crystal structure of the cytosolic Nudix-like domain of CD-NTase-associated protein 16 from Enterococcus faecalis.Acta crystallographica. Section F, Structural biology communications · 2026
    Article
  5. Article
  6. CBASS limits bacteriophage production while maintaining cell viability inbioRxiv : the preprint server for biology · 2026
    Article
  7. [Research on Bacteriophage Resistance: Coevolutionary Arms Race Between Bacteria and Phages Drives Novel Antibacterial Therapies].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2026
    Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Defence systems encoded by core genomic islands of seventh pandemicPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  14. Article
  15. Article
  16. Review
  17. Review
  18. Review
  19. Journal of bacteriology · 2024
    Article
  20. AJournal of bacteriology · 2024
    Article

27 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Geoffrey B SeverinDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824.
Miriam S RamlidenDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111.
Lisa A HawverDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111.
Kun WangDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824.ORCID 0000-0003-1715-990X
Macy E PellDepartment of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824.
Ann-Katrin KieningerDepartment of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824.
Atul KhataokarDepartment of Microbiology, Biochemistry, and Molecular Genetics, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ 07103.
Brendan J O'HaraDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111.
Lara V BehrmannDepartment of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824.
Matthew B NeiditchDepartment of Microbiology, Biochemistry, and Molecular Genetics, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ 07103.
Christoph BenningDepartment of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI 48824.ORCID 0000-0001-8585-3667
Christopher M WatersDepartment of Microbiology and Molecular Genetics, Michigan State University, East Lansing, MI 48824; watersc3@msu.edu Wai-Leung.Ng@tufts.edu.
Wai-Leung NgDepartment of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, MA 02111; watersc3@msu.edu Wai-Leung.Ng@tufts.edu.ORCID 0000-0002-8966-6604
Michigan State University · USTufts University · USRutgers, The State University of New Jersey · US

Funding

SIGNALING MECHANISMS IN VIBRIO CHOLERAE PARALLEL QUORUM SENSING PATHWAYSR01AI121337 · NIAID · TUFTS UNIVERSITY BOSTON · PI NG, WAI-LEUNG · 2016 to 2025
$4.5M
Infectious Disease Training-Pathogenesis/Host ResponseT32AI007329 · NIAID · TUFTS MEDICAL CENTER · PI HU, LINDEN T · 1988 to 2018
$4.1M
MOLECULAR GENETICS OF BASIC CELL FUNCTIONST32GM007310 · NIGMS · TUFTS UNIVERSITY BOSTON · PI CAMILLI, ANDREW · 1987 to 2020
$3.9M
From structure to systems: Understanding cyclic di-GMP control of transcriptionR01GM109259 · NIGMS · MICHIGAN STATE UNIVERSITY · PI WATERS, CHRISTOPHER M · 2015 to 2019
$2.0M
Molecular Mechanisms of Rgg Receptor Regulation by Pheromones and InhibitorsR01AI125452 · NIAID · RBHS-NEW JERSEY MEDICAL SCHOOL · PI FEDERLE, MICHAEL J, NEIDITCH, MATTHEW B · 2016 to 2019
$1.9M
Molecular mechanisms of adaptive diversity in Burkholderia biofilmsR01GM110444 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI COOPER, VAUGHN · 2015 to 2019
$1.5M
Developing novel technologies to address fundamental questions about second messenger signalingR03AI130554 · NIAID · MICHIGAN STATE UNIVERSITY · PI WATERS, CHRISTOPHER M · 2017 to 2018
$144k
NIAID NIH HHS R01 AI121337NIAID NIH HHS R01 AI125452NIAID NIH HHS R03 AI130554NIAID NIH HHS T32 AI007329NIGMS NIH HHS R01 GM109259NIGMS NIH HHS R01 GM110444NIGMS NIH HHS T32 GM007310
6 · The paper itself

Abstract

Sensing and responding to environmental changes is essential for bacteria to adapt and thrive, and nucleotide-derived second messengers are central signaling systems in this process. The most recently identified bacterial cyclic dinucleotide second messenger, 3', 3'-cyclic GMP-AMP (cGAMP), was first discovered in the El Tor biotype of

Indexed as

Bacterial ProteinsCell MembraneNucleotides, CyclicPhospholipasesSecond Messenger SystemsVibrio choleraeBacterial Proteinscyclic guanosine monophosphate-adenosine monophosphateNucleotides, CyclicPhospholipasescGAMPcyclic dinucleotidespathogenicity islandphospholipid metabolismsecond messengers

Identifiers

PMID29891656
PMCPMC6042076
OpenAlexW2808457005

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.