Evidence map›Paper›PMID 29891598›Full record

ArticleAntimicrobial agents and chemotherapy2018

Colistin Does Not Potentiate Ceftazidime-Avibactam Killing of Carbapenem-Resistant Enterobacteriaceae In Vitro or Suppress Emergence of Ceftazidime-Avibactam Resistance.

Ryan K Shields, M Hong Nguyen, Binghua Hao, Ellen G Kline, Cornelius J Clancy

Abstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Mutations inJAC-antimicrobial resistance · 2023
    Article
  9. Review
  10. Resistance to Ceftazidime/Avibactam inAntibiotics (Basel, Switzerland) · 2023
    Article
  11. Rapid diagnostics and ceftazidime/avibactam for KPC-producing Klebsiella pneumoniae bloodstream infections: impact on mortality and role of combination therapy.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2023
    Observational
  12. Frontiers in medicine · 2023
    Article
  13. Article
  14. Frontiers in pharmacology · 2022
    Article
  15. Article
  16. Review
  17. Review
  18. Frontiers in microbiology · 2021
    Article
  19. Review
  20. Frontiers in microbiology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Ryan K ShieldsDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
M Hong NguyenDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA mhn5@pitt.edu.
Binghua HaoXDR Pathogen Laboratory, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Ellen G KlineDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Cornelius J ClancyDepartment of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.

Funding

Caspofungin pharmacokinetics-pharmacodynamics during intra-adbominal candidiasisK08AI114883 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SHIELDS, RYAN K · 2015 to 2019
$858k
Evolution of KPC-K pneumoniae that persist in patients on prolonged antibioticsR21AI111037 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI CLANCY, CORNELIUS J · 2015 to 2016
$465k
Chromosomal and plasmid contributions to colistin resistance and virulence in KPC-producing Klebsiella pneumoniaeR21AI128338 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NGUYEN, M. HONG THI · 2017 to 2018
$444k
NIAID NIH HHS K08 AI114883NIAID NIH HHS R21 AI111037NIAID NIH HHS R21 AI128338
6 · The paper itself

Abstract

We tested ceftazidime-avibactam and colistin against 24 carbapenem-resistant

Indexed as

Anti-Bacterial AgentsAzabicyclo CompoundsCarbapenem-Resistant EnterobacteriaceaeCeftazidimeColistinDrug CombinationsDrug Resistance, Multiple, BacterialMicrobial Sensitivity TestsAnti-Bacterial Agentsavibactam, ceftazidime drug combinationAzabicyclo CompoundsCeftazidimeColistinDrug Combinationsantagonismceftazidime-avibactamcolistinCREKlebsiellaKlebsiella pneumoniaesynergy

Identifiers

PMID29891598
PMCPMC6105820

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.