ArticleGenes & development2018
A RhoA-YAP-c-Myc signaling axis promotes the development of polycystic kidney disease.
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Article in Genes & development, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 93 papers.
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93citing papers in PubMed
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Who cites it
93 citing papers in PubMed, 124 citations in OpenAlex.
- RhoA through its various effectors mediate mitochondrial fragmentation in polycystic kidney disease.iScience · 2026Article
- An integrin beta-1-anchored bicaudal C1-polycystin-1 module essential for tubular morphogenesis in polycystic kidney disease.iScience · 2026Article
- Cilia-to-basement membrane signaling is a biomechanical driver in models of autosomal dominant polycystic kidney disease.The Journal of clinical investigation · 2026Article
- Constitutive YAP activation in distal nephron segments disrupts epithelial identity and nephron patterning.JCI insight · 2026Article
- Kidney-specific deletion of the BicC family RNA-binding protein 1 triggers an ADPKD-like cystogenic program.iScience · 2026Article
- Modeling Complex Developmental Disease: The Case of Polycystic Kidney Disease.Journal of developmental biology · 2026Review
- Homer condensates orchestrate YAP-Wnt signaling crosstalk downstream of the Crumbs polarity complex.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The Ion channel, CFTR, assembles with HIPPO pathway proteins TAZ and YAP in polycystic kidney disease.The Journal of biological chemistry · 2026Article
- Transcriptional regulatory factors of the Aqp2 gene.Kidney research and clinical practice · 2026Article
- Polycystin-1 and Cardiac Remodeling: From Mechanotransduction to Clinical Consequences.Circulation research · 2026Review
- Intrinsic regulation of intestinal stem cell fate and homeostasis by Tet.bioRxiv : the preprint server for biology · 2026Article
- The YAP1 and EPHA3 receptor tyrosine kinase axis regulates cellular plasticity and treatment response.Cellular signalling · 2026Article
- Translational readthrough therapy for ADPKD induces polycystin1 expression and partially rescues functional deficits in PKD1 mutant cells.Scientific reports · 2025Article
- Polycystin-1 Mutant Alters Mechanotransduction in Response to Collagen and Extracellular Matrix Stiffness via Daam1-Dependent Microfilament Remodeling.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- mRNA (New York, N.Y.) · 2025Article
- The effect of tolvaptan on renal progression and systemic inflammation in ADPKD.Scientific reports · 2025Article
- Review
- The relationship between sperm secretion and the Hippo signaling pathway in the rat seminiferous tubules.Scientific reports · 2025Article
- Prostaglandin Analogs and Eupatilin as Treatments for Nephronophthisis.Kidney international reports · 2025Article
- Physiologic mechanisms underlying polycystic kidney disease.Physiological reviews · 2025Review
33 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors at 5 institutions in 2 countries.
Jing CaiDepartment of Physiology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Xuewen SongDivision of Nephrology, University Health Network, University of Toronto, Toronto, Ontario M5G 2N2, Canada.
Wei WangDepartment of Physiology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
Terry WatnickDepartment of Medicine, Division of Nephrology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
York PeiDivision of Nephrology, University Health Network, University of Toronto, Toronto, Ontario M5G 2N2, Canada.
Feng QianDepartment of Medicine, Division of Nephrology, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA.
Duojia PanDepartment of Physiology, Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
University Health Network · CAUniversity of Maryland, Baltimore · USHoward Hughes Medical Institute · USSouthwestern Medical Center · USThe University of Texas Southwestern Medical Center · US
Funding
Research BaseP30DK090868 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI WATNICK, TERRY J · 2010 to 2019
$11.1MComprehensive Analysis of Polycystin Related Endothelial Cell Signaling PathwaysR01DK095036 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI WATNICK, TERRY J · 2012 to 2021
$2.3MThe Molecular Mechanisms of Polycystin-1 Proteolytic Cleavage in Kidney Health and Polycystic Kidney DiseaseR01DK111611 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI QIAN, FENG · 2017 to 2021
$2.2MChemical probes targeting nuclear effector complex of the Hippo signaling pathwayR01DK098424 · NIDDK · UT SOUTHWESTERN MEDICAL CENTER · PI PAN, DUOJIA · 2014 to 2016
$1.1MThe Molecular Mechanisms of Polycystin-1 Proteolytic Cleavage in Kidney Health and Polycystic Kidney DiseaseR56DK111611 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI QIAN, FENG · 2016 to 2016
$116kHoward Hughes Medical InstituteNIDDK NIH HHS P30 DK090868NIDDK NIH HHS R01 DK095036NIDDK NIH HHS R01 DK098424NIDDK NIH HHS R01 DK111611NIDDK NIH HHS R56 DK111611
Abstract
Autosomal dominant polycystic kidney disease (ADPKD) is an inherited disorder caused by mutations in
Indexed as
Signal TransductionAdaptor Proteins, Signal TransducingAnimalsCell Cycle ProteinsCell LineCells, CulturedDisease Models, AnimalHEK293 CellsHumansKidneyMicePhosphoproteinsPolycystic Kidney DiseasesProto-Oncogene Proteins c-mycrhoA GTP-Binding Proteinrho GTP-Binding ProteinsAdaptor Proteins, Signal TransducingCell Cycle ProteinsPhosphoproteinsProto-Oncogene Proteins c-mycrhoA GTP-Binding ProteinRhoA protein, mouserho GTP-Binding ProteinsYap1 protein, mouseYAP-Signaling Proteins3D cultureADPKDc-MycHippo signalingRhoA signalingYAP/TAZ
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.