Evidence map›Paper›PMID 29891553›Full record

ArticleJournal of immunology (Baltimore, Md. : 1950)2018

CK2 Controls Th17 and Regulatory T Cell Differentiation Through Inhibition of FoxO1.

Sara A Gibson, Wei Yang, Zhaoqi Yan, Hongwei Qin, Etty N Benveniste

Abstract read
In one paragraph

Article in Journal of immunology (Baltimore, Md. : 1950), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. CK2B Induces CD8Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Frontiers in immunology · 2023
    Article
  15. Article
  16. Protein Kinase CK2 Controls CD8Journal of immunology (Baltimore, Md. : 1950) · 2022
    Article
  17. Akt isoforms in the immune system.Frontiers in immunology · 2022
    Review
  18. Review
  19. Review
  20. Protein Kinase CK2 Regulates B Cell Development and Differentiation.Journal of immunology (Baltimore, Md. : 1950) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sara A GibsonDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294.
Wei YangDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294.
Zhaoqi YanDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294.
Hongwei QinDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294 hqin@uab.edu tika@uab.edu.ORCID 0000-0002-7511-5078
Etty N BenvenisteDepartment of Cell, Developmental and Integrative Biology, University of Alabama at Birmingham, Birmingham, AL 35294 hqin@uab.edu tika@uab.edu.

Funding

XRAY CRYSTALLOGRAPHYP30CA013148 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Robert S Welner · 1985 to 2026
$165.9M
IMMUNOLOGIC DISEASES AND BASIC IMMUNOLOGYT32AI007051 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Laurie Ellen Harrington · 1985 to 2026
$13.1M
ROS Modulation of Innate and Adaptive Immunity in RAP30AR048311 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI MOUNTZ, JOHN D · 2001 to 2017
$9.5M
Therapeutic Intervention of the JAK/STAT Pathway for NeuroinflammationR01NS057563 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BENVENISTE, ETTY N · 2008 to 2017
$2.7M
The Role of CK2 in Glioblastoma DevelopmentR01CA194414 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BENVENISTE, ETTY N · 2016 to 2020
$1.7M
Targeting the JAK/STAT-3 Pathway Signaling Axis in GliomaR01CA158534 · NCI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BENVENISTE, ETTY N · 2012 to 2016
$1.5M
NCI NIH HHS P30 CA013148NCI NIH HHS R01 CA158534NCI NIH HHS R01 CA194414NIAID NIH HHS T32 AI007051NIAMS NIH HHS P30 AR048311NINDS NIH HHS R01 NS057563
6 · The paper itself

Abstract

Growing evidence demonstrates that the highly conserved serine/threonine kinase CK2 promotes Th17 cell differentiation while suppressing the generation of Foxp3

Indexed as

AnimalsCasein Kinase IICatalytic DomainCD4-Positive T-LymphocytesCell DifferentiationFemaleForkhead Box Protein O1Gene Expression RegulationLymphocyte ActivationMaleMicePhosphorylationTh17 CellsT-Lymphocytes, RegulatoryCasein Kinase IIForkhead Box Protein O1Foxo1 protein, mouse

Identifiers

PMID29891553
PMCPMC6040220

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.