Evidence map›Paper›PMID 29891548›Full record

ArticleInfection and immunity2018

Gain-of-Function Analysis Reveals Important Virulence Roles for the Yersinia pestis Type III Secretion System Effectors YopJ, YopT, and YpkA.

Samantha G Palace, Megan K Proulx, Rose L Szabady, Jon D Goguen

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Approaches for the Inactivation ofApplied biosafety : journal of the American Biological Safety Association · 2024
    Article
  5. Distinct Mechanisms of Type 3 Secretion System Recognition Control LTBbioRxiv : the preprint server for biology · 2024
    Article
  6. Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Samantha G PalaceDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA.ORCID https://orcid.org/0000-0002-7849-8078
Megan K ProulxDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA.ORCID https://orcid.org/0000-0002-9524-8302
Rose L SzabadyDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA.
Jon D GoguenDepartment of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts, USA jon.goguen@umassmed.edu.ORCID https://orcid.org/0000-0002-1372-1697
University of Massachusetts Chan Medical School · US

Funding

Innate Immunity Training ProgramT32AI095213 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SILVERMAN, NEAL · 2011 to 2025
$2.5M
NIAID NIH HHS T32 AI095213
6 · The paper itself

Abstract

Virulence of

Indexed as

Gain of Function MutationAnimalsApoptosisBacterial ProteinsCoculture TechniquesCysteine EndopeptidasesHumansMacrophagesMiceMice, Inbred C57BLNeutrophilsPhenotypeProtein Serine-Threonine KinasesType III Secretion SystemsVirulenceYersinia pestisBacterial ProteinsCysteine EndopeptidasesProtein Serine-Threonine KinasesType III Secretion SystemsYopP protein, YersiniaYopT protein, YersiniaypkA protein, YersiniaT3SStype III secretionYersinia pestisYopJYopTYpkA

Identifiers

PMID29891548
PMCPMC6105907
OpenAlexW2808117952

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.