Evidence map›Paper›PMID 29891540›Full record

ArticleInfection and immunity2018

Low Levels of T Cell Exhaustion in Tuberculous Lung Granulomas.

Eileen A Wong, Louis Joslyn, Nicole L Grant, Edwin Klein, Philana Ling Lin, Denise E Kirschner, JoAnne L Flynn

Open access · bronzeAbstract read
In one paragraph

Article in Infection and immunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. CD226 identifies effector CD8Cell reports · 2025
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  19. Cellular and molecular bioengineering · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Eileen A Wong *Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
Louis Joslyn *Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA.
Nicole L GrantDepartment of Infectious Disease and Microbiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, Pennsylvania, USA.
Edwin KleinDivision of Laboratory Animal Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Philana Ling LinDepartment of Pediatrics, University of Pittsburgh School of Medicine and Children's Hospital of UPMC, Pittsburgh, Pennsylvania, USA.
Denise E KirschnerDepartment of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, Michigan, USA kirschne@umich.edu joanne@pitt.edu.
JoAnne L FlynnDepartment of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA kirschne@umich.edu joanne@pitt.edu.ORCID https://orcid.org/0000-0001-7874-8981
University of Pittsburgh · USUniversity of Michigan · US

Funding

Predicting immune responses that correlate with protection against tuberculosisR01HL110811 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FLYNN, JOANNE L., KIRSCHNER, DENISE E · 2012 to 2016
$5.9M
Immunology of Infectious DiseaseT32AI060525 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI JoAnne L. Flynn · 2005 to 2026
$5.3M
Predicting protective T-cell responses in Tuberculosis using a systems biology approachR01AI123093 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI FLYNN, JOANNE L., KIRSCHNER, DENISE E · 2016 to 2020
$3.6M
A Multi-scale systems pharmacology approach to TB therapyU01HL131072 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI DARTOIS, VERONIQUE, FLYNN, JOANNE L. · 2016 to 2019
$2.9M
NHLBI NIH HHS R01 HL110811NHLBI NIH HHS U01 HL131072NIAID NIH HHS R01 AI123093NIAID NIH HHS T32 AI060525
6 · The paper itself

Abstract

The hallmarks of pulmonary

Indexed as

AnimalsCell MovementComputational BiologyCTLA-4 AntigenCytokinesGranulomaImmunity, CellularLungMacaca fascicularisMycobacterium tuberculosisProgrammed Cell Death 1 ReceptorT-LymphocytesTuberculosis, PulmonaryCTLA-4 AntigenCytokinesProgrammed Cell Death 1 Receptorcomputational biologygranulomaMycobacterium tuberculosisT cell exhaustion

Identifiers

PMID29891540
PMCPMC6105875
OpenAlexW2806464470

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.