Evidence map›Paper›PMID 29891510›Full record

ArticleBMJ case reports2018

Acute hepatitis E superinfection leading to chronic hepatitis B reactivation.

Aysha Aslam, Ammu Susheela, Sentia Iriana, Suzanne S Chan, Daryl Lau

Open access · bronzeAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in BMJ case reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. Life cycle and morphogenesis of the hepatitis E virus.Emerging microbes & infections · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Aysha AslamLiver Center, Division of Gastroenterology, Department of, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Ammu SusheelaLiver Center, Division of Gastroenterology, Department of, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Sentia IrianaLiver Center, Division of Gastroenterology, Department of, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Suzanne S ChanLiver Center, Division of Gastroenterology, Department of, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Daryl LauLiver Center, Division of Gastroenterology, Department of, Beth Israel Deaconess Medical Center, Boston, MA, USA.
Beth Israel Deaconess Medical Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reactivation of chronic hepatitis B (CHB) can be associated with significant morbidity and mortality. There are many different causes of hepatitis B reactivation. This case describes an Asian woman with stable CHB presenting with significant hepatitis flare with markedly elevated serum aminotransferases and hepatitis B virus DNA level. The clinical symptoms were subtle with fatigue and vague right upper quadrant tenderness. We ruled out drug-associated hepatotoxicity and screened for common causes of acute hepatitis. Interestingly, she was noted to have reactive anti-hepatitis E virus (HEV) IgM at initial presentation followed by anti-HEV IgG positivity a month later. The serological pattern confirmed the diagnosis of acute hepatitis E. The combination of antiviral therapy for hepatitis B and resolution of acute hepatitis E resulted in normalisation of serum aminotransferases. This case illustrates the importance of taking a careful history and having a high index of suspicion for various aetiologies when evaluating patients with reactivation of CHB.

Indexed as

Virus ActivationAdultDNA, ViralFemaleHepatitis B, ChronicHepatitis B virusHepatitis EHumansSuperinfectionDNA, Viralfoodborne infectionshepatitis Bhepatitis other

Identifiers

PMID29891510
PMCPMC6011448
OpenAlexW2807785034

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.