ArticleBMC complementary and alternative medicine2018
Anti diabetic property of aqueous extract of Stevia rebaudiana Bertoni leaves in Streptozotocin-induced diabetes in albino rats.
Article in BMC complementary and alternative medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 117 citations in OpenAlex.
- Steviol Glycosides (E960) FromFood science & nutrition · 2026Review
- Unravelling the role of natural herbs for the management of diabetes mellitus.Diabetology & metabolic syndrome · 2025Review
- The immunomodulator effect ofFood science & nutrition · 2024Article
- Nephroprotective Effect ofCurrent pharmaceutical design · 2024Article
- Microencapsulated antioxidant stevia fraction fortifies whey protein and enhances its antidiabetic activity.Journal of food science and technology · 2023Article
- Long-Term Consumption of Sucralose Induces Hepatic Insulin Resistance through an Extracellular Signal-Regulated Kinase 1/2-Dependent Pathway.Nutrients · 2023Article
- Melatonin downregulates the increased hepatic alpha-fetoprotein expression and restores pancreatic beta cells in a streptozotocin-induced diabetic rat model: a clinical, biochemical, immunohistochemical, and descriptive histopathological study.Frontiers in veterinary science · 2023Article
- Early Life Low-Calorie Sweetener Consumption Impacts Energy Balance during Adulthood.Nutrients · 2022Article
- Effect of stevia leaves (Food science & nutrition · 2022Review
- A New Labdane-Type Diterpene, 6-Biomedicines · 2022Article
- GlucoMedix®, an extract of Stevia rebaudiana and Uncaria tomentosa, reduces hyperglycemia, hyperlipidemia, and hypertension in rat models without toxicity: a treatment for metabolic syndrome.BMC complementary medicine and therapies · 2022Article
- Protective effects of Stevia rebaudiana extracts on beta cells in lipotoxic conditions.Acta diabetologica · 2022Article
- In-vivo and in-vitro evaluation of therapeutic potential of β- Carotene in diabetes.Journal of diabetes and metabolic disorders · 2021Article
- Natural sweetenerEXCLI journal · 2021Review
- Optimization of regeneration and Agrobacterium-mediated transformation of Stevia (Stevia rebaudiana Bertoni): a commercially important natural sweetener plant.Scientific reports · 2020Article
- Safety of a proposed amendment of the specifications for steviol glycosides (E 960) as a food additive: to expand the list of steviol glycosides to all those identified in the leaves ofEFSA journal. European Food Safety Authority · 2020Article
- Nanophytomedicines for the Prevention of Metabolic Syndrome: A Pharmacological and Biopharmaceutical Review.Frontiers in bioengineering and biotechnology · 2020Review
- Natural Alternative Sweeteners and Diabetes Management.Current diabetes reports · 2019Review
- Low-Dose Stevia (Rebaudioside A) Consumption Perturbs Gut Microbiota and the Mesolimbic Dopamine Reward System.Nutrients · 2019Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundStevia (Stevia rebaudiana) natural, non-caloric sugar substitute is rich source of pharmacologically important glycoside stevioside that is linked to the pathology and complications of diabetes.
methodsThe current research was carried out to explore the anti-diabetic effect of aqueous extract of Stevia rebaudiana leaves in albino rats. For this purpose, diabetes was induced by administration of streptozotocin (40 mg/kg body weight, intraperitoneally). The diabetic rats were administered with aqueous stevia extract at different dose levels (200, 300, 400 and 500 ppm/kg b.w) for 8 weeks; the control rats were fed basal diet during this period.
resultsStevia aqueous extract improved caloric management and weight control by decreasing the feed intake and body weight gain. Furthermore, intake of stevia extract resulted in significant (P < 0.05) decrease in the random blood glucose level (- 73.24%) and fasting blood glucose (- 66.09%) and glycosylated (HbA1c) hemoglobin (5.32%) while insulin (17.82 μIU/mL) and liver glycogen (45.02 mg/g) levels significantly improved in the diabetic rats, compared with the diabetic and non-diabetic control rats after 8 weeks study period.
conclusionsIt is concluded that aqueous extact of stevia has anti-diabetic effects in albino rats, and therefore could be promising nutraceutical therapy for the management of diabetes and its associated complications.
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