ArticleNeurorehabilitation and neural repair2018
Behavioral Effects of Chronic Gray and White Matter Stroke Lesions in a Functionally Defined Connectome for Naming.
Article in Neurorehabilitation and neural repair, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neural Resources Supporting Language Production vs. Comprehension in Chronic Post-stroke Aphasia: A Meta-Analysis Using Activation Likelihood Estimates.Frontiers in human neuroscience · 2021Pooled it
- Semantic and Phonological Brain Networks in Older Adults: A Systematic Scoping Review.Brain sciences · 2026Review
- Diffusion Tensor Imaging and Advanced Diffusion Imaging in Post-Stroke Aphasia Recovery.Tomography (Ann Arbor, Mich.) · 2026Review
- Causal contributions of left inferior and medial frontal cortex to semantic and executive control.Communications biology · 2025Article
- Advances in Neuromodulation Techniques for Aphasia Rehabilitation: A Comprehensive Review.Medical science monitor : international medical journal of experimental and clinical research · 2025Review
- Cerebral perfusion mediated by thalamo-cortical functional connectivity in non-dominant thalamus affects naming ability in aphasia.Human brain mapping · 2022Article
- Remote cortical atrophy and language outcomes after chronic left subcortical stroke with aphasia.Frontiers in neuroscience · 2022Article
- Indirect White Matter Pathways Are Associated With Treated Naming Improvement in Aphasia.Neurorehabilitation and neural repair · 2021Article
- Structural white matter connectometry of word production in aphasia: an observational study.Brain : a journal of neurology · 2020Observational
- The utility of lesion classification in predicting language and treatment outcomes in chronic stroke-induced aphasia.Brain imaging and behavior · 2019Article
- Neural structures supporting spontaneous and assisted (entrained) speech fluency.Brain : a journal of neurology · 2019Article
- A Taxonomy of Brain-Behavior Relationships After Stroke.Journal of speech, language, and hearing research : JSLHR · 2019Review
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundIn functional magnetic resonance imaging studies, picture naming engages widely distributed brain regions in the parietal, frontal, and temporal cortices. However, it remains unknown whether those activated areas, along with white matter pathways between them, are actually crucial for naming.
objectiveWe aimed to identify nodes and pathways implicated in naming in healthy older adults and test the impact of lesions to the connectome on naming ability.
methodsWe first identified 24 cortical nodes activated by a naming task and reconstructed anatomical connections between these nodes using probabilistic tractography in healthy adults. We then used structural scans and fractional anisotropy (FA) maps in 45 patients with left hemisphere stroke to assess the relationships of node and pathway integrity to naming, phonology, and nonverbal semantic ability.
resultsWe found that mean FA values in 13 left hemisphere white matter tracts within the dorsal and ventral streams and 1 interhemispheric tract significantly related to naming scores after controlling for lesion size and demographic factors. In contrast, lesion loads in the cortical nodes were not related to naming performance after controlling for the same variables. Among the identified tracts, the integrity of 4 left hemisphere ventral stream tracts related to nonverbal semantic processing and 1 left hemisphere dorsal stream tract related to phonological processing.
conclusionsOur findings reveal white matter structures vital for naming and its subprocesses. These findings demonstrate the value of multimodal methods that integrate functional imaging, structural connectivity, and lesion data to understand relationships between brain networks and behavior.
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