Evidence map›Paper›PMID 29890851›Full record

ArticleAutoimmunity2018

Race/ethnicity is an independent risk factor for autoimmune hepatitis among the San Francisco underserved.

Briton Lee, Edward W Holt, Robert J Wong, Justin L Sewell, Ma Somsouk, Mandana Khalili, Jacquelyn J Maher, Michele M Tana

Open access · greenAbstract read
In one paragraph

Article in Autoimmunity, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.1field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 30 citations in OpenAlex.

  1. Article
  2. Review
  3. The Geoepidemiology of Autoimmune Hepatitis.Clinical reviews in allergy & immunology · 2026
    Review
  4. Pathogenesis, Non-Invasive Assessments and Treatment of Hepatic Fibrosis in Autoimmune Liver Diseases.Liver international : official journal of the International Association for the Study of the Liver · 2025
    Review
  5. Article
  6. Article
  7. Review
  8. Article
  9. Current status of disparity in liver disease.World journal of hepatology · 2022
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Briton Leea School of Medicine , University of California San Francisco , San Francisco , CA , USA.
Edward W Holtb Division of Hepatology, Department of Transplant , California Pacific Medical Center , San Francisco , CA , USA.
Robert J Wongc Division of Gastroenterology and Hepatology , Alameda Health System, Highland Hospital , Oakland , CA , USA.
Justin L Sewelld Department of Medicine, Division of Gastroenterology , University of California San Francisco , San Francisco , CA , USA.
Ma Somsoukd Department of Medicine, Division of Gastroenterology , University of California San Francisco , San Francisco , CA , USA.
Mandana Khalilid Department of Medicine, Division of Gastroenterology , University of California San Francisco , San Francisco , CA , USA.
Jacquelyn J Maherd Department of Medicine, Division of Gastroenterology , University of California San Francisco , San Francisco , CA , USA.
Michele M Tanad Department of Medicine, Division of Gastroenterology , University of California San Francisco , San Francisco , CA , USA.
University of California, San Francisco · USAlameda Health System · USCalifornia Pacific Medical Center · US

Funding

UCSF Liver Core CenterP30DK026743 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Jennifer Y. Chen · 1986 to 2026
$30.7M
Mentoring Multidisciplinary Patient-Oriented Research in Viral HepatitisK24AA022523 · NIAAA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KHALILI, MANDANA · 2013 to 2023
$1.9M
NIAAA NIH HHS K24 AA022523NIDDK NIH HHS P30 DK026743
6 · The paper itself

Abstract

Although autoimmune hepatitis (AIH) is more common in women and affects people of all races/ethnicities, there is currently limited information regarding the relationship between race/ethnicity and AIH, especially in the context of underserved populations. We aim to evaluate the relationship between race/ethnicity and AIH and better characterize its clinical features among different racial groups. We conducted a 15-year retrospective analysis, from January 2002 to June 2017, of patients seen at Zuckerberg San Francisco General Hospital (ZSFG). Sixty-three AIH patients and 2049 non-AIH controls were eligible for the study. The main predictor of interest was race/ethnicity, and the main outcome of interest was AIH diagnosis; other secondary measures recorded include clinical features such as ALT, bilirubin, and biopsy fibrosis at presentation. In a multivariable model adjusting for age and sex, we found that black (OR 9.6, 95% CI 1.8-178), Latino (OR 25.0, 95% CI 5.3-448), and Asian/Pacific Islander (API) (OR 10.8, 95% CI 2.2-196) race/ethnicity were associated with increased odds of an AIH diagnosis compared to the white reference group. Among people of colour with AIH, there were no significant differences in baseline ALT (p = .45), total bilirubin at presentation (p = .06), fibrosis at presentation (p = .74), and hospitalization (p = .27). Race/ethnicity is an independent risk factor for AIH. The clinical features of AIH did not differ significantly among black, Latino, and API patients.

Indexed as

Health Status DisparitiesAdultAgedAged, 80 and overEthnicityFemaleHepatitis, AutoimmuneHumansMaleMiddle AgedPrevalenceRacial GroupsRetrospective StudiesRisk FactorsSan FranciscoVulnerable PopulationsAutoimmune liver diseaseliverliver fibrosisoutcomes researchrace/ethnicity

Identifiers

PMID29890851
PMCPMC6311708
OpenAlexW2808706857

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.