Evidence map›Paper›PMID 29890505›Full record

ArticleAquatic toxicology (Amsterdam, Netherlands)2018

Comparative effects of cadmium, zinc, arsenic and chromium on olfactory-mediated neurobehavior and gene expression in larval zebrafish (Danio rerio).

Kevin Heffern, Keith Tierney, Evan P Gallagher

Open access · greenAbstract readComparative Study
In one paragraph

Article in Aquatic toxicology (Amsterdam, Netherlands), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
5.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 46 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Ecotoxicological Effects of Potassium Dichromate on the Tadpole ShrimpAnimals : an open access journal from MDPI · 2024
    Article
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  7. Review
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Kevin HeffernDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105-6099, United States.
Keith TierneyDepartment of Biological Sciences, University of Alberta, Edmonton, AB T6G 2R3, Canada.
Evan P GallagherDepartment of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98105-6099, United States. Electronic address: evang3@uw.edu.
University of Washington · USUniversity of Alberta · CA

Funding

WILDLIFE BIOMARKER APPLICATIONS TO REMEDIATION DECISION MAKINGP42ES004696 · NIEHS · UNIVERSITY OF WASHINGTON · PI FURLONG, CLEMENT EUGENE · 1987 to 2021
$51.2M
XENOBIOTIC BIOTRANSFORMATION AND DISPOSITIONP30ES007033 · NIEHS · UNIVERSITY OF WASHINGTON · PI Sheela Sathyanarayana · 1995 to 2026
$42.5M
NIEHS NIH HHS P30 ES007033NIEHS NIH HHS P42 ES004696
6 · The paper itself

Abstract

Studies have shown that olfactory-mediated behaviors that are critical to survival can be disrupted by exposure to certain metals. Polluted waterways often contain elevated levels of metals, yet only a subset have been characterized for their potential to cause olfactory toxicity. A larval zebrafish behavioral assay was developed to characterize concentration-response curves for zinc (Zn), hexavalent chromium (Cr), and arsenate (As) olfaction inhibition. Cadmium (Cd), an established olfactory toxicant, was used as a positive control. As expected, following a 24-hour exposure to Cd, we observed a reduced response to taurocholic acid (TCA), a substrate for ciliated olfactory sensory neurons (OSNs), thus validating the behavioral assay. Zn exposure similarly decreased the olfactory response toward TCA, (IC

Indexed as

AnimalsAntioxidantsArsenicBehavior, AnimalCadmiumChromiumGene Expression Regulation, DevelopmentalLarvaMetallothioneinNervous SystemOxidative StressRNA, MessengerSmellWater Pollutants, ChemicalZebrafishZebrafish ProteinsAntioxidantsArsenicCadmiumChromiumchromium hexavalent ionMetallothioneinRNA, MessengerWater Pollutants, ChemicalZebrafish ProteinsZincAntioxidant gene expressionMetallothioneinMetalsOlfactionOlfactory sensory neuronsZebrafish

Identifiers

PMID29890505
PMCPMC6062444
OpenAlexW2807426968

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.