Evidence map›Paper›PMID 29890324›Full record

ArticleNeuroImage2019

White matter injury in term neonates with congenital heart diseases: Topology & comparison with preterm newborns.

Ting Guo, Vann Chau, Shabnam Peyvandi, Beatrice Latal, Patrick S McQuillen, Walter Knirsch, Anne Synnes, Maria Feldmann, Nadja Naef, M Mallar Chakravarty and 4 more

Open access · greenAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 2 pooled it
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 2 syntheses or guidelines pooled it, 83 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Review
  5. Article
  6. Article
  7. The "Heart-and-Brain Interaction" in Newborns with Complex Congenital Heart Disease.European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery · 2025
    Article
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  9. Observational
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  12. Born too young or too blue tips the scaling of a folded brain.Proceedings of the National Academy of Sciences of the United States of America · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 7 institutions in 3 countries.

Ting GuoNeurosciences and Mental Health, The Hospital for Sick Children Research Institute, Toronto, ON, Canada; Department of Paediatrics, The Hospital for Sick Children and the University of Toronto, Toronto, ON, Canada.
Vann ChauNeurosciences and Mental Health, The Hospital for Sick Children Research Institute, Toronto, ON, Canada; Department of Paediatrics, The Hospital for Sick Children and the University of Toronto, Toronto, ON, Canada.
Shabnam PeyvandiDepartment of Pediatric Cardiology, Benioff Children's Hospital and University of California, San Francisco, CA, USA.
Beatrice LatalChild Development Center, University Children's Hospital, Zurich, Switzerland.
Patrick S McQuillenDepartment of Pediatrics, Benioff Children's Hospital and University of California, San Francisco, CA, USA.
Walter KnirschDepartment of Pediatric Cardiology, University Children's Hospital, Zurich, Switzerland.
Anne SynnesDepartment of Pediatrics, University of British Columbia, BC Children's Hospital Research Institute, Vancouver, BC, Canada.
Maria FeldmannChild Development Center, University Children's Hospital, Zurich, Switzerland.
Nadja NaefChild Development Center, University Children's Hospital, Zurich, Switzerland.
M Mallar ChakravartyCerebral Imaging Centre, Douglas Mental Health Research Institute, Verdun, QC, Canada; Department of Psychiatry, McGill University, Montreal, QC, Canada; Biological and Biomedical Engineering, McGill University, Montreal, QC, Canada.
Alessandra De PetrilloNeurosciences and Mental Health, The Hospital for Sick Children Research Institute, Toronto, ON, Canada.
Emma G DuerdenNeurosciences and Mental Health, The Hospital for Sick Children Research Institute, Toronto, ON, Canada; Department of Paediatrics, The Hospital for Sick Children and the University of Toronto, Toronto, ON, Canada.
A James BarkovichDepartment of Radiology, Benioff Children's Hospital and University of California, San Francisco, CA, USA.
Steven P MillerNeurosciences and Mental Health, The Hospital for Sick Children Research Institute, Toronto, ON, Canada; Department of Paediatrics, The Hospital for Sick Children and the University of Toronto, Toronto, ON, Canada. Electronic address: steven.miller@sickkids.ca.
Hospital for Sick Children · CAUniversity Children's Hospital Zurich · CHUCSF Benioff Children's Hospital · USBC Children's Hospital · CAMcGill University · CASickKids Foundation · CAUniversity of California, San Francisco · US

Funding

ZIDOVUDINE &LAMIVUDINE &NEVIRAPINE COMBINATION THERAPY IN HIV 1 INFM01RR001271 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KESSLER, DAVID A · 1985 to 2006
$22.7M
White matter injury as predictor of outcome in neonatal brain injuryP50NS035902 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FERRIERO, DONNA M. · 1997 to 2012
$14.0M
Repair in High Risk Newborns with Congential Heart DiseaseP01NS082330 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI XU, DUAN · 2014 to 2018
$6.0M
3D MR SPECTROSCOPIC IMAGING OF THE NEWBORN BRAINR01NS040117 · NINDS · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI VIGNERON, DANIEL B · 2001 to 2005
$1.9M
Fetal markers of neurodevelopmental outcomes in congenital heart diseaseK23NS099422 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PEYVANDI, SHABNAM · 2017 to 2021
$961k
White Matter Injury in Critical Ill Newborns With Congenital Heart DiseaseR01NS063876 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MCQUILLEN, PATRICK SEAN · 2009 to 2010
$833k
NINDS NIH HHS K23 NS099422NINDS NIH HHS P01 NS082330NINDS NIH HHS P50 NS035902NINDS NIH HHS R01 NS040117NINDS NIH HHS R01 NS063876
6 · The paper itself

Abstract

backgroundNeonates with congenital heart disease (CHD) are at high risk of punctate white matter injury (WMI) and impaired brain development. We hypothesized that WMI in CHD neonates occurs in a characteristic distribution that shares topology with preterm WMI and that lower birth gestational age (GA) is associated with larger WMI volume.

objective(1) To quantitatively assess the volume and location of WMI in CHD neonates across three centres. (2) To compare the volume and spatial distribution of WMI between term CHD neonates and preterm neonates using lesion mapping.

methodsIn 216 term born CHD neonates from three prospective cohorts (mean birth GA: 39 weeks), WMI was identified in 86 neonates (UBC: 29; UCSF: 43; UCZ: 14) on pre- and/or post-operative T1 weighted MRI. WMI was manually segmented and volumes were calculated. A standard brain template was generated. Probabilistic WMI maps (total, pre- and post-operative) were developed in this common space. Using these maps, WMI in the term CHD neonates was compared with that in preterm neonates: 58 at early-in-life (mean postmenstrual age at scan 32.2 weeks); 41 at term-equivalent age (mean postmenstrual age at scan 40.1 weeks).

resultsThe total WMI volumes of CHD neonates across centres did not differ (p = 0.068): UBC (median = 84.6 mm

conclusionsWMI in term neonates with CHD occurs in a characteristic topology. The spatial distribution of WMI in term neonates with CHD reflects the expected maturation of pre-oligodendrocytes such that the central regions are less vulnerable than in the preterm neonates.

Indexed as

BrainBrain InjuriesFemaleHeart Defects, CongenitalHumansInfant, NewbornInfant, PrematureMagnetic Resonance ImagingMaleWhite MatterCongenital heart disease (CHD)Preterm neonatesProbabilistic WMI mapTerm CHD neonatesTopologyWhite matter injury (WMI)

Identifiers

PMID29890324
PMCPMC6289608
OpenAlexW2807852901

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.