Evidence map›Paper›PMID 29890293›Full record

ArticleNeuroscience2018

Roles of TRPV1 and TRPA1 in Spontaneous Pain from Inflamed Masseter Muscle.

Sheng Wang, Benjamin Brigoli, Jongseuk Lim, Alisha Karley, Man-Kyo Chung

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuroscience, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 45 citations in OpenAlex.

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  10. Trigeminal somatosensation in the temporomandibular joint and associated disorders.Frontiers in pain research (Lausanne, Switzerland) · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Sheng WangDepartment of Neural and Pain Sciences, School of Dentistry, Program in Neuroscience, Center to Advance Chronic Pain Research, University of Maryland, Baltimore, 650 W. Baltimore Street, Baltimore, MD 21201, USA.
Benjamin BrigoliDepartment of Neural and Pain Sciences, School of Dentistry, Program in Neuroscience, Center to Advance Chronic Pain Research, University of Maryland, Baltimore, 650 W. Baltimore Street, Baltimore, MD 21201, USA.
Jongseuk LimDepartment of Neural and Pain Sciences, School of Dentistry, Program in Neuroscience, Center to Advance Chronic Pain Research, University of Maryland, Baltimore, 650 W. Baltimore Street, Baltimore, MD 21201, USA.
Alisha KarleyDepartment of Neural and Pain Sciences, School of Dentistry, Program in Neuroscience, Center to Advance Chronic Pain Research, University of Maryland, Baltimore, 650 W. Baltimore Street, Baltimore, MD 21201, USA.
Man-Kyo ChungDepartment of Neural and Pain Sciences, School of Dentistry, Program in Neuroscience, Center to Advance Chronic Pain Research, University of Maryland, Baltimore, 650 W. Baltimore Street, Baltimore, MD 21201, USA. Electronic address: mchung@umaryland.edu.
University of Maryland, Baltimore · US

Funding

Genetic and post-translational modifications of TRPV1 in craniofacial painR01DE023846 · NIDCR · UNIVERSITY OF MARYLAND BALTIMORE · PI CHUNG, MAN-KYO · 2014 to 2018
$1.9M
NIDCR NIH HHS R01 DE023846
6 · The paper itself

Abstract

Craniofacial muscle pain, such as spontaneous pain and bite-evoked pain, are major symptoms in patients with temporomandibular disorders and infection. However, the underlying mechanisms of muscle pain, especially mechanisms of highly prevalent spontaneous pain, are poorly understood. Recently, we reported that transient receptor potential vanilloid 1 (TRPV1) contributes to spontaneous pain but only marginally contributes to bite-evoked pain during masseter inflammation. Here, we investigated the role of transient receptor potential ankyrin 1 (TRPA1) in spontaneous and bite-evoked pain during masseter inflammation, and dissected the relative contributions of TRPA1 and TRPV1. Masseter inflammation increased mouse grimace scale (MGS) scores and face wiping behaviors. Pharmacological or genetic inhibition of TRPA1 significantly attenuated MGS but not face wiping behaviors. MGS scores were also attenuated by scavenging putative endogenous ligands for TRPV1 or TRPA1. Simultaneous inhibition of TRPA1 by AP18 and TRPV1 by AMG9810 in masseter muscle resulted in robust inhibition of both MGS and face wiping behaviors. Administration of AP18 or AMG9810 to masseter muscle induced conditioned place preference (CPP). The extent of CPP following simultaneous administration of AP18 and AMG9810 was greater than that induced by the individual antagonists. In contrast, inflammation-induced reduction of bite force was not affected by the inhibition of TRPA1 alone or in combination with TRPV1. These results suggest that simultaneous inhibition of TRPV1 and TRPA1 produces additive relief of spontaneous pain, but does not ameliorate bite-evoked pain during masseter inflammation. Our results provide further evidence that distinct mechanisms underlie spontaneous and bite-evoked pain from inflamed masseter muscle.

Indexed as

AcrylamidesAnimalsBehavior, AnimalBridged Bicyclo Compounds, HeterocyclicConditioning, OperantInflammationMasseter MuscleMiceMyalgiaOximesPain MeasurementTRPA1 Cation ChannelTRPV Cation Channels3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo(b)(1,4)dioxin-6-yl)acrylamide4-(4-chlorophenyl)-3-methylbut-3-en-2-oximeAcrylamidesBridged Bicyclo Compounds, HeterocyclicOximesTRPA1 Cation ChannelTrpa1 protein, mouseTRPV1 protein, mouseTRPV Cation Channelsinflammationmuscle paintrigeminal painTRP channels

Identifiers

PMID29890293
PMCPMC6086573
OpenAlexW2805998634

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.