Evidence map›Paper›PMID 29890123›Full record

ArticleChest2018

Visual Estimate of Coronary Artery Calcium Predicts Cardiovascular Disease in COPD.

Surya P Bhatt, Ella A Kazerooni, John D Newell, John E Hokanson, Matthew J Budoff, Chandra A Dass, Carlos H Martinez, Sandeep Bodduluri, Francine L Jacobson, Andrew Yen and 4 more

Registry-linked trialOpen access · bronzeAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Chest, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00608764 (Genetic Epidemiology of Chronic Obstructive Pulmonary Disease), which is not on this map. Cited by 31 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 2 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00608764 active not recruitingnot on this map

Genetic Epidemiology of Chronic Obstructive Pulmonary Disease (COPDGene)

TypeobservationalSponsorBrigham and Women's HospitalRan2007 to 2028Enrolled10,718ConditionsPulmonary Disease, Chronic Obstructive, Emphysema, Bronchitis, Chronic
3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 46 citations in OpenAlex.

  1. Methods to assess atherosclerotic cardiovascular risk in chronic respiratory diseases: a systematic review.European respiratory review : an official journal of the European Respiratory Society · 2025
    Pooled it
  2. Pooled it
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  5. Article
  6. Observational
  7. Article
  8. Review
  9. Observational
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  11. Article
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  15. Coronary artery calcification detected by initial polytrauma CT in severely injured patients: retrospective single-center cohort study.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024
    Article
  16. Article
  17. Review
  18. Associations Between Coronary Artery Calcium Score and Exacerbation Risk in BLOCK-COPD.Chronic obstructive pulmonary diseases (Miami, Fla.) · 2024
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 10 institutions in 1 country.

Surya P BhattDivision of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL; UAB Lung Health Center, University of Alabama at Birmingham, Birmingham, AL; UAB Lung Imaging Core, University of Alabama at Birmingham, Birmingham, AL. Electronic address: sbhatt@uabmc.edu.
Ella A KazerooniDepartment of Radiology, University of Michigan, Ann Arbor, MI.
John D NewellDepartment of Radiology, University of Iowa, Iowa City, IA.
John E HokansonDepartment of Epidemiology, University of Colorado Anschutz Medical Campus, Aurora, CO.
Matthew J BudoffLos Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA.
Chandra A DassDepartment of Radiology, Temple University Hospital, Philadelphia, PA.
Carlos H MartinezDivision of Pulmonary and Critical Care Medicine, University of Michigan, Ann Arbor, MI.
Sandeep BodduluriDivision of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL; UAB Lung Health Center, University of Alabama at Birmingham, Birmingham, AL; UAB Lung Imaging Core, University of Alabama at Birmingham, Birmingham, AL.
Francine L JacobsonDepartment of Radiology, Brigham and Women's Hospital, Boston, MA.
Andrew YenDepartment of Radiology, University of California at San Diego, San Diego, CA.
Mark T DransfieldDivision of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, AL; UAB Lung Health Center, University of Alabama at Birmingham, Birmingham, AL; UAB Lung Imaging Core, University of Alabama at Birmingham, Birmingham, AL; Birmingham VA Medical Center, Birmingham, AL.
Carl FuhrmanDepartment of Radiology, University of Pittsburgh Medical Center, Pittsburgh, PA.
Hrudaya NathUAB Lung Imaging Core, University of Alabama at Birmingham, Birmingham, AL; Department of Radiology, University of Alabama at Birmingham, Birmingham, AL.
COPDGene Investigators
University of Alabama at Birmingham · USUniversity of Michigan–Ann Arbor · USBirmingham VA Medical Center · USBrigham and Women's Hospital · USHarbor–UCLA Medical Center · USTemple University Hospital · USUniversity of California, San Diego · USUniversity of Colorado Anschutz Medical Campus · USUniversity of Iowa · USUniversity of Pittsburgh Medical Center · US

Funding

Genetic Epidemiology of COPDU01HL089897 · NHLBI · NATIONAL JEWISH HEALTH · PI CRAPO, JAMES D · 2007 to 2021
$56.9M
Genetic Epidemiology of COPDU01HL089856 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI SILVERMAN, EDWIN K · 2007 to 2021
$20.7M
Diastolic Dysfunction and Pauci-inflammatory Acute Exacerbations of Chronic Obstructive Pulmonary DiseaseK23HL133438 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BHATT, SURYA P. · 2016 to 2020
$921k
UAB Mentoring Program in COPD Patient Oriented ResearchK24HL140108 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DRANSFIELD, MARK T · 2018 to 2022
$439k
NHLBI NIH HHS K23 HL133438NHLBI NIH HHS K24 HL140108NHLBI NIH HHS U01 HL089856NHLBI NIH HHS U01 HL089897
6 · The paper itself

Abstract

backgroundCOPD is associated with cardiovascular disease (CVD), and coronary artery calcification (CAC) provides additional prognostic information. With increasing use of nongated CT scans in clinical practice, this study hypothesized that the visual Weston CAC score would perform as well as the Agatston score in predicting prevalent and incident coronary artery disease (CAD) and CVD in COPD.

methodsCAC was measured by using Agatston and Weston scores on baseline CT scans in 1,875 current and former smokers enrolled in the Genetic Epidemiology of COPD (COPDGene) study. Baseline cardiovascular disease and incident cardiac events on longitudinal follow-up were recorded. Accuracy of the CAC scores was measured by using receiver-operating characteristic analysis, and Cox proportional hazards analyses were used to estimate the risk of incident cardiac events.

resultsCAD was reported by 133 (7.1%) subjects at baseline. A total of 413 (22.0%) and 241 (12.9%) patients had significant CAC according to the Weston (≥ 7) and Agatston (≥ 400) scores, respectively; the two methods were significantly correlated (r = 0.84; P < .001). Over 5 years of follow-up, 127 patients (6.8%) developed incident CVD. For predicting prevalent CAD, c-indices for the Weston and Agatston scores were 0.78 and 0.74 and for predicting incident CVD, they were 0.62 and 0.61. After adjustment for age, race, sex, smoking pack-years, FEV

conclusionsA simple visual score for CAC performed well in predicting incident CAD in smokers with and without COPD. TRIAL REGISTRY: ClinicalTrials.gov; No.: NCT00608764; URL: www.clinicaltrials.gov.

Indexed as

Coronary VesselsAgedCalcinosisCardiovascular DiseasesFemaleFollow-Up StudiesHumansLongitudinal StudiesMaleMiddle AgedPredictive Value of TestsPrognosisPulmonary Disease, Chronic ObstructiveRisk FactorsSmokersTomography, X-Ray Computedcardiovascular diseaseCOPDcoronary calcification

Identifiers

PMID29890123
PMCPMC6130328
OpenAlexW2805466679

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.