ArticlePloS one2018
Clinicopathological characteristics and outcomes of rare histologic subtypes of gallbladder cancer over two decades: A population-based study.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 62 citations in OpenAlex.
- Gallbladder malignancy in the setting of Mirizzi syndrome with bile duct involvement: a case report.Journal of surgical case reports · 2026Article
- Liver metastasis-specific mortality in patients with primary gallbladder carcinoma: a competing risk model analysis based on the SEER database.Discover oncology · 2026Article
- Surgical setting of initial cholecystectomy influences prognosis in incidentally detected gallbladder carcinoma.Ecancermedicalscience · 2026Article
- Review
- Gallbladder Squamous Cell Carcinoma with Diffuse β-hCG Expression: A Case Report and Review of the Literature.Journal of gastrointestinal cancer · 2025Review
- Primary Squamous Cell Carcinoma of the Gallbladder: Case Report.Clinical case reports · 2024Article
- What eliminates the chance for cure: a multi-center evaluation on 10-year follow-up of gallbladder cancer after surgical resection.Annals of medicine · 2024Article
- Risk factors and survival prediction model establishment for prognosis in patients with radical resection of gallbladder cancer.World journal of gastrointestinal surgery · 2024Article
- Risk Factors and Prognostic Factors in GBC.Journal of clinical medicine · 2024Review
- New trends in diagnosis and management of gallbladder carcinoma.World journal of gastrointestinal oncology · 2024Review
- Application of contrast-enhanced ultrasonography for gallbladder squamous cell carcinoma: a case report.Frontiers in oncology · 2024Article
- Article
- Therapeutic response analysis for patients with adenosquamous carcinoma of the gallbladder: data analysis based on the Surveillance, Epidemiology, and End Results (SEER) database.Journal of gastrointestinal oncology · 2023Article
- Article
- Development and validation of an online dynamic prognostic nomogram for incidental gallbladder adenocarcinoma patients without distant metastasis after surgery: a population-based study.Frontiers in medicine · 2023Article
- APEX1 predicts poor prognosis of gallbladder cancer and affects biological properties of CD133Journal of Cancer · 2023Article
- Gallbladder Cancer: A Single-Institution 10-Year Experience-Analysis of Adenocarcinoma Subtypes and Tumors Arising from Intracholecystic Papillary Neoplasms.Annals of surgical oncology · 2022Article
- Development and validation of a prognostic nomogram for gallbladder cancer patients after surgery.BMC gastroenterology · 2022Article
- Review
- An unusual cause of abdominal pain.Przeglad gastroenterologiczny · 2022Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThere is limited literature about the clinicopathological characteristics and outcomes of rare histologic variants of gallbladder cancer (GBC).
methodsUsing SEER database, surgically managed GBC patients with microscopically confirmed adenocarcinoma, adenosquamous/squamous cell carcinoma and papillary carcinoma were identified from 1988 to 2009. Patients with second primary cancer and distant metastasis at presentation were excluded. The effect of clinicopathological variables on overall survival (OS) and disease specific survival (DSS) were analyzed using univariate and multivariate proportional hazards modeling. All associations were considered statistically significant at an alpha error of 0.01.
resultsOut of 4738 cases, 217 adenosquamous/squamous (4.6%), 367 papillary (7.7%), and 4154 adenocarcinomas (87.7%) were identified. Median age was 72 years. Higher tumor grade (grade 2, 3, 4 versus grade 1), higher T stage (T2, T3, T4 versus T1), lymph node positivity (N1 versus N0) and adenosquamous/squamous histology (versus adenocarcinoma) had worse OS and DSS (p < .001). Papillary GBC had better OS and DSS than adenocarcinoma (HR = 0.7; p < .001). Radical surgery (versus simple cholecystectomy) had better OS (HR = 0.83, p = 0.002) in multivariate analysis. OS rates at 3 and 5 years were 0.56 and 0.44 for papillary, 0.3 and 0.22 for adenocarcinoma, and 0.14 and 0.12 for adenosquamous/squamous histology, while DSS rates at 3 and 5 years were 0.67 and 0.61 for papillary, 0.38 and 0.31 for adenocarcinoma, and 0.17 and 0.16 for adenosquamous/squamous subtypes respectively.
conclusionPapillary GBC had better survival outcomes while adenosquamous/squamous GBC had worse survival outcomes compared to gallbladder adenocarcinoma.
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