Observational studyPloS one2018
Red cell distribution width and renal outcome in patients with non-dialysis-dependent chronic kidney disease.
Observational study in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Prognostic value of RDW and its derivatives in ICU patients with hypertensive chronic kidney disease.BMC cardiovascular disorders · 2026Article
- Article
- Association of red blood cell distribution width/albumin ratio with renal prognosis among patients with type 2 diabetes mellitus: A retrospective cohort study.Journal of diabetes investigation · 2025Article
- Prioritizing Patient Selection in Clinical Trials: A Machine Learning Algorithm for Dynamic Prediction of In-Hospital Mortality for ICU Admitted Patients Using Repeated Measurement Data.Journal of clinical medicine · 2025Article
- The Prognostic Role of RDW in Hospitalized Heart Failure Patients with and Without Chronic Kidney Disease.Journal of clinical medicine · 2024Article
- Article
- Predicting CKD progression using time-series clustering and light gradient boosting machines.Scientific reports · 2024Article
- Impact of red blood cell distribution width-albumin ratio on prognosis of patients with CKD.Scientific reports · 2023Article
- Nrf2 alleviates spaceflight-induced immunosuppression and thrombotic microangiopathy in mice.Communications biology · 2023Article
- Red blood cell distribution width improves the prediction of 28-day mortality for patients with sepsis-induced acute kidney injury: A retrospective analysis from MIMIC-IV database using propensity score matching.Journal of intensive medicine · 2023Article
- Prognostic significance of increased preoperative red cell distribution width (RDW) and changes in RDW for colorectal cancer.Cancer medicine · 2023Article
- Is red cell distribution width a prognostic factor in patients with breast cancer? A meta-analysis.Frontiers in surgery · 2023Review
- Can CBC Profile and Liver Function Test Predict Chronic Kidney Disease among a Normal Population?International journal of preventive medicine · 2023Article
- Red Blood Cell Distribution Width Is Associated With Adverse Kidney Outcomes in Patients With Chronic Kidney Disease.Frontiers in medicine · 2022Article
- Distribution Width of Red Blood Cells and Related Factors Among Patients with End-Stage Renal Disease in Addis Ababa, Ethiopia.Journal of blood medicine · 2022Article
- Hematological Parameters and Clinical Features in Patients with Advanced Chronic Kidney Disease.Yonago acta medica · 2020Article
- Genetic predisposition for increased red blood cell distribution width is an early risk factor for cardiovascular and renal comorbidities.Disease models & mechanisms · 2020Article
- Increased red cell width distribution to lymphocyte ratio is a predictor of histologic severity in primary biliary cholangitis.Medicine · 2018Observational
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Higher red cell distribution width (RDW) has been reported to predict mortality among patients with various diseases, including chronic kidney disease (CKD). However, whether RDW is associated with renal outcome remains unclear. We investigated the relationship between RDW and renal outcome in patients with non-dialysis-dependent CKD (NDD-CKD). This prospective, observational study of patients with CKD was conducted at a single nephrology department. First, we performed regression analyses for the decline in estimated glomerular filtration rate (eGFR) during the first 3 months of observation to determine its short-term association with RDW. Next, we categorized baseline RDW into two groups by its median (13.5%) and performed Cox regression analyses to investigate whether higher RDW was an independent predictor of renal outcomes defined as a composite of the initiation of dialysis and doubling of the serum creatinine concentration. Furthermore, we repeated the analyses to confirm whether the transition of the RDW category during the first 3 months would also predict renal outcomes. We enrolled 703 patients. Baseline RDW showed a non-linear association with the eGFR decline during the first 3 months, with a greater negative correlation at the lower end of the RDW distribution. Over a median follow-up of 1.8 years, 178 patients (25.3%) reached the renal endpoint. Multivariable Cox regression analyses showed that patients with higher RDW had a higher risk of developing renal outcomes (adjusted hazard ratio [HR]: 1.47, 95% confidence interval [CI]: 1.05-2.07) than did those with lower RDW. Furthermore, patients with sustained, higher RDW demonstrated a significantly higher risk than did those with consistently lower RDW (adjusted HR: 1.65, 95% CI: 1.02-2.67). In conclusion, higher RDW was independently associated with worse renal outcome in patients with NDD-CKD. RDW could be an additional prognostic marker of the progression of CKD.
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