ArticlePloS one2018
Risk of acute epiglottitis in patients with preexisting diabetes mellitus: A population-based case-control study.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 34 citations in OpenAlex.
- Active Emergency Management of Adult Acute Epiglottitis: An Analysis of 570 Cases.World journal of otorhinolaryngology - head and neck surgery · 2026Article
- [Clinical characteristics and risk factors of recurrent acute infectious epiglottitis in adults].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2023Article
- A Case of Adult Epiglottitis in a Patient With Uncontrolled Diabetes and Occupational Risks.Cureus · 2022Article
- Elevated risk of acute epiglottitis in patients with chronic obstructive pulmonary disease: A nationwide cohort study.PloS one · 2022Article
- Factors Affecting Patients with Concurrent Deep Neck Infection and Acute Epiglottitis.Diagnostics (Basel, Switzerland) · 2021Article
- Type 2 Diabetes Mellitus Increases Peritonsillar Abscess Susceptibility: Real-World Evidence.Clinical and experimental otorhinolaryngology · 2021Article
- High Risk of Peritonsillar Abscess in End-Stage Renal Disease Patients: A Nationwide Real-World Cohort Study.International journal of environmental research and public health · 2021Article
- Real-world evidence and optimization of vocal dysfunction in end-stage renal disease patients with secondary hyperparathyroidism.Scientific reports · 2021Article
- End-stage renal disease as a risk factor for epiglottitis: a population-based cohort study in Taiwan.BMJ open · 2020Article
- Deep Neck Infection in Systemic Lupus Erythematosus Patients: Real-World Evidence.Scientific reports · 2020Article
- Death related to epiglottitis.Forensic science, medicine, and pathology · 2020Article
- The Association Between Decompensated Liver Cirrhosis and Deep Neck Infection: Real-World Evidence.International journal of environmental research and public health · 2019Article
- Real-World Database Examining the Association between Sjögren's Syndrome and Chronic Rhinosinusitis.Journal of clinical medicine · 2019Article
- High Risk of Deep Neck Infection in Patients with Type 1 Diabetes Mellitus: A Nationwide Population-Based Cohort Study.Journal of clinical medicine · 2018Article
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveStudies have revealed that 3.5%-26.6% of patients with epiglottitis have comorbid diabetes mellitus (DM). However, whether preexisting DM is a risk factor for acute epiglottitis remains unclear. In this study, our aim was to explore the relationship between preexisting DM and acute epiglottitis in different age and sex groups by using population-based data in Taiwan.
methodsWe analyzed data between January 2000 and December 2013 obtained from the Taiwan National Health Insurance Research Database. The case group consisted of 2,393 patients with acute epiglottitis. The control group comprised 9,572 individuals without epiglottitis, frequency matched by sex, age, urbanization level, and income. Underlying DM was retrospectively assessed in the cases and controls. Univariate and multivariate logistic regression analyses were used to investigate the associations between underlying DM and acute epiglottitis.
resultsOf the 2,393 patients, 180 (7.5%) had preexisting DM, whereas only 530 (5.5%) of the 9,572 controls had preexisting DM. Multivariate logistic regression analyses indicated that preexisting DM was significantly associated with acute epiglottitis (adjusted odds ratio [aOR] = 1.42, 95% confidence interval [CI] = 1.15-1.75, P = 0.004). Subgroup analysis showed that the association between DM and epiglottitis remained significant for men (aOR = 1.57, 95% CI: 1.19-2.08, p = 0.002) but not for women. Age-stratified analysis revealed a significant association between DM and acute epiglottitis in patients aged 35-64 years. Use of anti-diabetic agents was not significantly associated with the development of acute epiglottitis among diabetic patients, including oral hypoglycemic agents (OHA) alone (aOR = 0.88, 95% CI = 0.53-1.46, p = 0.616), and OHA combined with insulin/ insulin alone (aOR = 1.30, 95% CI = 0.76-2.22, p = 0.339). The association between presence of diabetes complications and the occurrence of acute epiglottitis was also not significant among diabetic patients in this study setting (aOR = 0.86, 95% CI = 0.59-1.26, p = 0.439).
conclusionsThe results of our large-scale population-based case-control study indicate that preexisting DM is one of the possible factors associated with the development of acute epiglottitis. Physicians should pay attention to the symptoms and signs of acute epiglottitis in DM patients, particularly in men aged 35-64 years.
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