Evidence map›Paper›PMID 29889842›Full record

ArticlePloS one2018

Whole genome sequence and comparative analysis of Borrelia burgdorferi MM1.

Neda Jabbari, Gustavo Glusman, Lena M Joesch-Cohen, Panga Jaipal Reddy, Robert L Moritz, Leroy Hood, Christopher G Lausted

Open access · goldAbstract readComparative Study
In one paragraph

Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Lyme Disease in Humans.Current issues in molecular biology · 2021
    Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Neda JabbariInstitute for Systems Biology, Seattle, Washington, United States of America.
Gustavo GlusmanInstitute for Systems Biology, Seattle, Washington, United States of America.ORCID 0000-0001-8060-5955
Lena M Joesch-CohenInstitute for Systems Biology, Seattle, Washington, United States of America.ORCID 0000-0002-9129-6809
Panga Jaipal ReddyInstitute for Systems Biology, Seattle, Washington, United States of America.
Robert L MoritzInstitute for Systems Biology, Seattle, Washington, United States of America.ORCID 0000-0002-3216-9447
Leroy HoodInstitute for Systems Biology, Seattle, Washington, United States of America.
Christopher G LaustedInstitute for Systems Biology, Seattle, Washington, United States of America.ORCID 0000-0003-3073-9212
Institute for Systems Biology · USBrown University · US

Funding

Quantitative Systems BiologyP50GM076547 · NIGMS · INSTITUTE FOR SYSTEMS BIOLOGY · PI BALIGA, NITIN S · 2006 to 2016
$30.6M
Novel peptide based biomarkers for Lyme disease diagnosticsR21AI133335 · NIAID · INSTITUTE FOR SYSTEMS BIOLOGY · PI MORITZ, ROBERT L · 2018 to 2019
$522k
NIAID NIH HHS R21 AI133335NIGMS NIH HHS P50 GM076547
6 · The paper itself

Abstract

Lyme disease is caused by spirochaetes of the Borrelia burgdorferi sensu lato genospecies. Complete genome assemblies are available for fewer than ten strains of Borrelia burgdorferi sensu stricto, the primary cause of Lyme disease in North America. MM1 is a sensu stricto strain originally isolated in the midwestern United States. Aside from a small number of genes, the complete genome sequence of this strain has not been reported. Here we present the complete genome sequence of MM1 in relation to other sensu stricto strains and in terms of its Multi Locus Sequence Typing. Our results indicate that MM1 is a new sequence type which contains a conserved main chromosome and 15 plasmids. Our results include the first contiguous 28.5 kb assembly of lp28-8, a linear plasmid carrying the vls antigenic variation system, from a Borrelia burgdorferi sensu stricto strain.

Indexed as

AnimalsBacterial Typing TechniquesBorrelia burgdorferiBorrelia burgdorferi GroupChromosome MappingComparative Genomic HybridizationDNA, BacterialGenetic VariationGenome, BacterialHigh-Throughput Nucleotide SequencingHumansLyme DiseaseMultilocus Sequence TypingDNA, Bacterial

Identifiers

PMID29889842
PMCPMC5995427
OpenAlexW2949425956

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.