ArticlePLoS genetics2018
Genetic dissection of stress-induced reproductive arrest in Drosophila melanogaster females.
Article in PLoS genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 78 citations in OpenAlex.
- A Tale of Two States: Similarities and Differences in Neuropeptide Signaling in Larval and Adult Drosophila.The Journal of comparative neurology · 2026Review
- A Peptidergic Neural System Connects the Circadian Clock to the Photoperiodic Control of Reproductive Diapause in the BugThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Altered circadian rhythm, sleep, andProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Drosophila ezoana uses morning and evening oscillators to adjust its rhythmic activity to different daylengths but only the morning oscillator to measure night length for photoperiodic responses.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024Article
- Neural mechanism of circadian clock-based photoperiodism in insects and snails.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024Review
- The circadian and photoperiodic clock of the pea aphid.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024Review
- Pigment-dispersing factor is present in circadian clock neurons of pea aphids and may mediate photoperiodic signalling to insulin-producing cells.Open biology · 2023Article
- Female reproductive dormancy in Drosophila is regulated by DH31-producing neurons projecting into the corpus allatum.Development (Cambridge, England) · 2023Article
- Seasonal cues act through the circadian clock and pigment-dispersing factor to control EYES ABSENT and downstream physiological changes.Current biology : CB · 2023Article
- Signaling through the dystrophin glycoprotein complex affects the stress-dependent transcriptome in Drosophila.Disease models & mechanisms · 2023Article
- The genomic basis of copper tolerance in Drosophila is shaped by a complex interplay of regulatory and environmental factors.BMC biology · 2022Article
- Environmentally responsive reproduction: neuroendocrine signalling and the evolution of eusociality.Current opinion in insect science · 2022Review
- Clock gene-dependent glutamate dynamics in the bean bug brain regulate photoperiodic reproduction.PLoS biology · 2022Article
- WAKE-mediated modulation of cVA perception via a hierarchical neuro-endocrine axis in Drosophila male-male courtship behaviour.Nature communications · 2022Article
- Photoperiod-Dependent Expression of MicroRNA inInternational journal of molecular sciences · 2022Article
- Recovery from cold-induced reproductive dormancy is regulated by temperature-dependent AstC signaling.Current biology : CB · 2022Article
- Pool-GWAS on reproductive dormancy in Drosophila simulans suggests a polygenic architecture.G3 (Bethesda, Md.) · 2022Article
- Article
- Endocrine Regulation of Lifespan in Insect Diapause.Frontiers in physiology · 2022Review
- Neuropeptide F signaling regulates parasitoid-specific germline development and egg-laying in Drosophila.PLoS genetics · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
By genetic manipulations, we study the roles played by insulin-producing cells (IPCs) in the brain and their target, the corpora allata (CA), for reproductive dormancy in female Drosophila melanogaster, which is induced by exposing them to a combination of low temperature (11°C), short-day photoperiod (10L:14D) and starvation (water only) for 7 days immediately after eclosion (dormancy-inducing conditions). Artificial inactivation of IPCs promotes, whereas artificial activation impedes, the induction of reproductive dormancy. A transcriptional reporter assay reveals that the IPC activity is reduced when the female flies are exposed to dormancy-inducing conditions. The photoperiod sensitivity of reproductive dormancy is lost in pigment-dispersing factor (pdf), but not cry, mutants, suggesting that light input to IPCs is mediated by pdf-expressing neurons. Genetic manipulations to upregulate and downregulate insulin signaling in the CA, a pair of endocrine organs that synthesize the juvenile hormone (JH), decrease and increase the incidence of reproductive dormancy, respectively. These results demonstrate that the IPC-CA axis constitutes a key regulatory pathway for reproductive dormancy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.