Observational studyPloS one2018
Renal resistive index as an early predictor and discriminator of acute kidney injury in critically ill patients; A prospective observational cohort study.
Observational study in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Relation Between the Renal Resistive Index and Markers of the Systemic Circulation, the Microcirculation, Fluid Status and of Renal Function.
Determination of the Value of Neutrophil Gelatinase-associated Lipocalin and Renal Resistive Index in the Diagnosis and Prognosis of Sepsis-associated Acute Kidney Injury
Who cites it
33 citing papers in PubMed, 82 citations in OpenAlex.
- Renal resistive index-guided mean arterial pressure titration in sepsis: a prospective single-center, single-blind, parallel-group randomized controlled trial.Nature communications · 2026Trial
- Combined plasma syndecan-1 and renal resistive index as early predictors of sepsis-associated Acute kidney injury: a prospective observational study.Renal failure · 2026Observational
- Human biomarker navigator.iMeta · 2026Review
- Impact of Parathyroidectomy on Vascular Stiffness: Exploring Pulse Wave Velocity and Renal Resistive Index.The Journal of clinical endocrinology and metabolism · 2026Article
- Diagnostic Significance of Renal Artery Resistive Index (RRI), Caudal Vena Cava Diameter (CVC), and Aorta (Ao) in Dogs with Hypovolemia.Veterinary sciences · 2026Article
- What new renal biomarkers tell us about renal physiology: Collection: physiology applied to ICU.Annals of intensive care · 2026Review
- Renal Resistive Index in Severe Preeclampsia: Correlation With Glomerular Filtration Rate and Diagnostic Accuracy for Acute Kidney Injury.International journal of nephrology · 2026Article
- B-Mode Ultrasound May Be an Early Marker in Acute Kidney Injury.Diagnostics (Basel, Switzerland) · 2025Article
- Current applications and research trends of ultrasound examination in acute kidney injury assessment: a bibliometric analysis.International urology and nephrology · 2025Article
- Exploring the Utility of Renal Resistive Index in Critical Care: Insights into ARDS and Cardiac Failure.Biomedicines · 2025Review
- Diagnostic value of multi-parameter ultrasound evaluation in sepsis complicated by acute kidney injury.Renal failure · 2024Article
- Impact of positive end-expiratory pressure on renal resistive index in mechanical ventilated patients.Journal of clinical monitoring and computing · 2024Article
- Advancements in Trauma-Induced Acute Kidney Injury: Diagnostic and Therapeutic Innovations.Life (Basel, Switzerland) · 2024Review
- Discussion of hemodynamic optimization strategies and the canonical understanding of hemodynamics during biventricular mechanical support in cardiogenic shock: does the flow balance make the difference?Clinical research in cardiology : official journal of the German Cardiac Society · 2024Article
- Renal medullary perfusion differs from that in renal cortex in patients with sepsis associated acute kidney injury and correlates with renal function prognosis: A prospective cohort study.Clinical hemorheology and microcirculation · 2024Article
- Nephroangiosclerosis not related to hypertension: A matter to resolve in the era of precision medicine.Journal of human hypertension · 2023Article
- Influence of arterial blood gases on the renal arterial resistive index in intensive care unit.Journal of translational medicine · 2023Observational
- Predictability performance of urinary C-C motif chemokine ligand 14 and renal resistive index for persistent sepsis-associated acute kidney injury in ICU patients.International urology and nephrology · 2023Observational
- Renal arterial resistive index, monocyte chemotactic protein 1 and neutrophil gelatinase-associated lipocalin, for predicting acute kidney injury in critically ill cancer patients.International urology and nephrology · 2023Article
- Current Insights into the Significance of the Renal Resistive Index in Kidney and Cardiovascular Disease.Diagnostics (Basel, Switzerland) · 2023Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute kidney injury (AKI) complicates shock. Diagnosis is based on rising creatinine, a late phenomenon. Intrarenal vasoconstriction occurs earlier. Measuring flow resistance in the renal circulation, Renal Resistive Index (RRI), could become part of vital organ function assessment using Doppler ultrasound. Our aim was to determine whether RRI on ICU admission is an early predictor and discriminator of AKI developed within the first week.
methodsIn this prospective cohort of mixed ICU patients with and without shock, RRI was measured <24-h of admission. Besides routine variables, sublingual microcirculation and bioelectrical impedance were measured. AKI was defined by the Kidney Disease Improving Global Outcomes criteria. Uni- and multivariate regression and Receiver Operating Characteristics curve analyses were performed.
resultsNinety-nine patients were included, median age 67 years (IQR 59-75), APACHE III score 67 (IQR 53-89). Forty-nine patients (49%) developed AKI within the first week. AKI patients had a higher RRI on admission than those without: 0.71 (0.69-0.73) vs. 0.65 (0.63-0.68), p = 0.001. The difference was significant for AKI stage 2: RRI = 0.72 (0.65-0.80) and 3: RRI = 0.74 (0.67-0.81), but not for AKI stage 1: RRI = 0.67 (0.61-0.74). On univariate analysis, RRI significantly predicted AKI 2-3: OR 1.012 (1.006-1.019); Area Under the Curve (AUC) of RRI for AKI 2-3 was 0.72 (0.61-0.83), optimal cut-off 0.74, sensitivity 53% and specificity 87%. On multivariate analysis, RRI remained significant, independent of APACHE III and fluid balance; adjusted OR: 1.008 (1.000-1.016).
conclusionsHigh RRI on ICU admission was a significant predictor for development of AKI stage 2-3 during the first week. High RRI can be used as an early warning signal RRI, because of its high specificity. A combined score including RRI, APACHE III and fluid balance improved AKI prediction, suggesting that vasoconstriction or poor vascular compliance, severity of disease and positive fluid balance independently contribute to AKI development.
trial registrationClinicalTrials.gov NCT02558166.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.