Evidence map›Paper›PMID 29889312›Full record

ReviewMass spectrometry reviews2020

DNA adducts: Formation, biological effects, and new biospecimens for mass spectrometric measurements in humans.

Byeong Hwa Yun, Jingshu Guo, Medjda Bellamri, Robert J Turesky

Abstract readReview
In one paragraph

Review in Mass spectrometry reviews, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Unveiling Urinary Mutagenicity by the Ames Test for Occupational Risk Assessment: A Systematic Review.International journal of environmental research and public health · 2022
    Pooled it
  2. Pooled it
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Frequent Detection of Abasic Sites andChemical research in toxicology · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Epitranscriptomic alterations induced by environmental toxins: implications for RNA modifications and disease.Genes and environment : the official journal of the Japanese Environmental Mutagen Society · 2025
    Review
  16. Mapping assays to the key characteristics of carcinogens to support decision-making.Database : the journal of biological databases and curation · 2025
    Article
  17. Article
  18. Article
  19. Article
  20. Review

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Byeong Hwa YunMasonic Cancer Center and Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN.
Jingshu GuoMasonic Cancer Center and Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN.
Medjda BellamriMasonic Cancer Center and Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN.
Robert J TureskyMasonic Cancer Center and Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN.

Funding

Women's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Jeffrey S. Miller · 1998 to 2026
$100.4M
Chemical markers of heterocyclic aromatic amines for human biomonitoringR01CA122320 · NCI · WADSWORTH CENTER · PI TURESKY, ROBERT J. · 2007 to 2018
$4.8M
DNA adductomics of the urinary systemR01CA220367 · NCI · UNIVERSITY OF MINNESOTA · PI ROSENQUIST, THOMAS A, TURESKY, ROBERT J. · 2017 to 2022
$3.0M
New biomonitoring methodologies to measure DNA adducts in human tissuesR01ES019564 · NIEHS · WADSWORTH CENTER · PI TURESKY, ROBERT J. · 2011 to 2020
$2.8M
Carcinogen DNA adduct biomarkers in formalin fixed tissuesR33CA186795 · NCI · UNIVERSITY OF MINNESOTA · PI TURESKY, ROBERT J. · 2014 to 2016
$982k
Novel approach to measure DNA adducts in humansR21ES014438 · NIEHS · WADSWORTH CENTER · PI TURESKY, ROBERT J. · 2006 to 2007
$356k
NCI NIH HHS P30 CA077598NCI NIH HHS R01 CA122320NCI NIH HHS R01 CA220367NCI NIH HHS R33 CA186795NIEHS NIH HHS R01 ES019564NIEHS NIH HHS R21 ES014438
6 · The paper itself

Abstract

Hazardous chemicals in the environment and diet or their electrophilic metabolites can form adducts with genomic DNA, which can lead to mutations and the initiation of cancer. In addition, reactive intermediates can be generated in the body through oxidative stress and damage the genome. The identification and measurement of DNA adducts are required for understanding exposure and the causal role of a genotoxic chemical in cancer risk. Over the past three decades,

Indexed as

AnimalsBiopsyChromatography, LiquidDNA AdductsHumansMass SpectrometryMutationNeoplasmsDNA AdductsbiomarkerbiomonitoringcarcinogenDNA adductmass spectrometry

Identifiers

PMID29889312
PMCPMC6289887

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.