Evidence map›Paper›PMID 29889080›Full record

ReviewJournal of Parkinson's disease2018

Assessing the Efficacy of Cell Transplantation for Parkinson's Disease: A Patient-Centered Approach.

Stephen Polgar, Leila Karimi, Melissa Buultjens, Meg E Morris, Monica Busse

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of Parkinson's disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Review
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Stephen PolgarSchool of Allied Health, La Trobe University, Bundoora, Melbourne, Australia.
Leila KarimiSchool of Psychology and Public Health, La Trobe University, Bundoora, Melbourne, Australia.
Melissa BuultjensSchool of Psychology and Public Health, La Trobe University, Bundoora, Melbourne, Australia.
Meg E MorrisLa Trobe Centre for Sport and Exercise Medicine Research, School Allied Health, La Trobe University and Healthscope, Bundoora, Melbourne, Australia.
Monica BusseCentre For Trials Research, Cardiff University, Cardiff, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEvidence from a growing number of preclinical studies indicate that recently discovered stem cell lines may be translated into viable cellular therapies for people with Parkinson's disease.

objectivesIn a brief but critical review, we examine the use of primary and secondary outcome measures currently used to evaluate the efficacy of cellular therapies.

methodsThe current practice of relying on a single primary outcome measure does not appear to provide the evidence required for demonstrating the robust, life-changing recovery anticipated with the successful implementation of cellular therapies.

resultsWe propose a 360-degree assessment protocol, which includes co-primary and composite outcome measures to provide accurate and comprehensive evidence of treatment efficacy, from the perspectives of both the researchers and the patients.

Indexed as

Activities of Daily LivingCell TransplantationPatient-Centered CareHumansParkinson DiseaseQuality of LifeTreatment Outcome360 degree assessmentCell transplantationParkinson’s diseasepatient-centered approach

Identifiers

PMID29889080
PMCPMC6130410

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.