ArticleThe British journal of radiology2018
Relationship between MRI quantified small bowel motility and abdominal symptoms in Crohn's disease patients-a validation study.
Article in The British journal of radiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Motion Mitigation Techniques for Abdominal and Cardiac MR Imaging.Journal of magnetic resonance imaging : JMRI · 2026Review
- The Evolving Role of Cine MRI in Crohn's Disease: From Functional Motility Analysis to Precision Management: A Review of the Last 10 Years.Diagnostics (Basel, Switzerland) · 2025Review
- Effects of patient and imaging factors on small bowel motility scores derived from deep learning-based segmentation of cine MRI.European radiology · 2025Article
- Quantified small bowel motility assessment on magnetic resonance enterography in paediatric inflammatory bowel disease - does it reflect clinical response?Pediatric radiology · 2024Article
- Motility Mapping Quantification Using the Classical Optical Flow Algorithm for Small Bowel Crohn's Disease: Comparison with Balloon-assisted Enteroscopy Findings.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2023Article
- Magnetic resonance imaging assessed enteric motility and luminal content analysis in patients with severe bloating and visible distension.Neurogastroenterology and motility · 2022Article
- Discrete Shearlets as a Sparsifying Transform in Low-Rank Plus Sparse Decomposition for Undersampled (Journal of imaging · 2022Article
- Quantitative assessment of terminal ileum motility on MR enterography in Crohn disease: a feasibility study in children.European radiology · 2021Article
- Dynamic Colon Model (DCM): A Cine-MRI Informed Biorelevant In Vitro Model of the Human Proximal Large Intestine Characterized by Positron Imaging Techniques.Pharmaceutics · 2020Article
- Abnormal gut motility in inflammatory bowel disease: an update.Techniques in coloproctology · 2020Review
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8 authors.
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Abstract
objectivePrevious single-centre MRI data suggests an inverse correlation between normal small bowel motility variance and abdominal symptoms in Crohn's disease (CD) patients. The current work prospectively assesses this observation in a larger, two-centre study.
methodsMR enterography datasets were analysed from 82 patients (38 male, aged 16-68), who completed a contemporaneous Harvey-Bradshaw index (HBI) questionnaire. Dynamic "cine motility" breath-hold balanced steady-state free precession sequences were acquired through the whole small bowel (SB) volume. Regions of interest (ROIs) were manually applied to encompass all morphologically normal SB (i.e. excluding Crohn's affected bowel) and a validated registration technique used to produce motility maps. Mean and variance motility metrics were correlated with HBI and symptom components (well-being, pain and diarrhoea) using Spearman's correlation statistics.
resultsOverall, motility variance was non-significantly negatively correlated with the total HBI score, (r = -0.17, p = 0.12), but for subjects with a HBI score over 10, the negative correlation was significant (r = -0.633, p = 0.027). Motility variance was negatively correlated with diarrhoea (r = -0.29, p < 0.01). No significant correlation was found between mean motility and HBI (r = -0.02, p = 0.84).
conclusionAn inverse association between morphologically normal small bowel motility variance and patient symptoms has been prospectively confirmed in patients with HBI scores above 10. This association is particularly apparent for the symptom of diarrhoea. Advances in knowledge: This study builds on preliminary work by confirming in a large, well-controlled prospective multicentre study a relationship between normal bowel motility variance and patient reported symptoms which may have implications for drug development and clinical management.
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