ArticleThe Journal of physiology2018
Inter-cortical modulation from premotor to motor plasticity.
Article in The Journal of physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Safety and recommendations for TMS use in healthy subjects and patient populations, with updates on training, ethical and regulatory issues: Expert Guidelines.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2021Guideline
- Modulation of human primary motor cortex plasticity during proactive and retroactive interference between motor practice and paired associative stimulation.Experimental brain research · 2026Article
- Interleaved premotor rTMS does not affect motor sequence learning.Scientific reports · 2026Article
- Absence of evidence for post-training tDCS effects on motor memory consolidation and premotor-primary motor cortex interaction: a resting-state EEG study.Frontiers in human neuroscience · 2026Article
- Modulation of dorsal premotor cortex differentially influences I-wave excitability in primary motor cortex of young and older adults.The Journal of physiology · 2023Article
- The behavioral and neural effects of parietal theta burst stimulation on the grasp network are stronger during a grasping task than at rest.Frontiers in neuroscience · 2023Article
- Short-term arm immobilization modulates excitability of inhibitory circuits within, and between, primary motor cortices.Physiological reports · 2022Article
- Microstructural Properties of Human Brain Revealed by Fractional Anisotropy Can Predict the After-Effect of Intermittent Theta Burst Stimulation.Cerebral cortex communications · 2022Article
- Offline low-frequency rTMS of the primary and premotor cortices does not impact motor sequence memory consolidation despite modulation of corticospinal excitability.Scientific reports · 2021Article
- Intensity dependent effect of cognitive training on motor cortical plasticity and cognitive performance in humans.Experimental brain research · 2020Article
- Theta burst stimulation in humans: a need for better understanding effects of brain stimulation in health and disease.Experimental brain research · 2020Review
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
key pointsSynaptic plasticity is involved in daily activities but abnormal plasticity may be deleterious. In this study, we found that motor plasticity could be modulated by suppressing the premotor cortex with the theta burst form of repetitive transcranial magnetic stimulation. Such changes in motor plasticity were associated with reduced learning of a simple motor task. We postulate that the premotor cortex adjusts the amount of motor plasticity to modulate motor learning through heterosynaptic metaplasticity. The present results provide an insight into how the brain physiologically coordinates two different areas to bring them into a functional network, a concept that could be employed to intervene in diseases with abnormal plasticity. ABSTRACT: Primary motor cortex (M1) plasticity is known to be influenced by the excitability and prior activation history of M1 itself. However, little is known about how its plasticity is influenced by other areas of the brain. In the present study on humans of either sex who were known to respond to theta burst stimulation from previous studies, we found plasticity of M1 could be modulated by suppressing the premotor cortex with the theta burst form of repetitive transcranial magnetic stimulation. Motor plasticity was distorted and disappeared 30 min and 120 min, respectively, after premotor excitability was suppressed. Further evaluation revealed that such changes in motor plasticity were associated with impaired learning of a simple motor task. We postulate that the premotor cortex modulates the amount of plasticity within M1 through heterosynaptic metaplasticity, and that this may impact on learning of a simple motor task previously shown to be directly affected by M1 plasticity. The present results provide an insight into how the brain physiologically coordinates two different areas to bring them into a functional network. Furthermore, such concepts could be translated into therapeutic approaches for diseases with aberrant plasticity.
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