Evidence map›Paper›PMID 29888766›Full record

ArticleJournal of neuroscience and neuropharmacology2018

Post-Traumatic Stress Disorder Delineating the Progression and Underlying Mechanisms Following Blast Traumatic Brain Injury.

Brandon Lucke-Wold, Richard Nolan, Divine Nwafor, Linda Nguyen, Cletus Cheyuo, Ryan Turner, Charles Rosen, Robert Marsh

Abstract read
In one paragraph

Article in Journal of neuroscience and neuropharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Brandon Lucke-WoldDepartment of Neurosurgery, West Virginia University School of Medicine, Morgantown, WV, USA.
Richard NolanDepartment of Neurosurgery, West Virginia University School of Medicine, Morgantown, WV, USA.
Divine NwaforDepartment of Neurosurgery, West Virginia University School of Medicine, Morgantown, WV, USA.
Linda NguyenDepartment of Pediatric Neurology, University of California San Diego, San Diego, CA, USA.
Cletus CheyuoDepartment of Neurosurgery, West Virginia University School of Medicine, Morgantown, WV, USA.
Ryan TurnerDepartment of Neurosurgery, West Virginia University School of Medicine, Morgantown, WV, USA.
Charles RosenDepartment of Neurosurgery, West Virginia University School of Medicine, Morgantown, WV, USA.
Robert MarshDepartment of Neurosurgery, West Virginia University School of Medicine, Morgantown, WV, USA.

Funding

West Virginia IDEA-CTRU54GM104942 · NIGMS · WEST VIRGINIA UNIVERSITY · PI Sally Lynn Hodder · 2012 to 2026
$81.0M
NIGMS NIH HHS U54 GM104942
6 · The paper itself

Abstract

Posttraumatic Stress Disorder (PTSD) is a devastating condition that can develop after blast Traumatic Brain Injury (TBI). Ongoing work has been performed to understand how PTSD develops after injury. In this review, we highlight how PTSD affects individuals, discuss what is known about the physiologic changes to the hypothalamic pituitary axis and neurotransmitter pathways, and present an overview of genetic components that may predispose individuals to developing PTSD. We then provide an overview of current treatment strategies to treat PTSD in veterans and present new strategies that may be useful going forward. The need for further clinical and pre-clinical studies is imperative to improve diagnosis, treatment, and management for patients that develop PTSD following blast TBI.

Indexed as

Blast traumatic brain injuryHypothalamic pituitary axisMolecular mechanismsNovel treatmentsPosttraumatic stress disorder

Identifiers

PMID29888766
PMCPMC5993449

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.