ArticleHuman reproduction open2018
The Environment and Reproductive Health (EARTH) Study: A Prospective Preconception Cohort.
Article in Human reproduction open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 99 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
99 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Systematic literature review and meta-analysis on the reproductive effects of micro- pollutants in humans and animals.Frontiers in toxicology · 2025Pooled it
- Female dietary patterns and outcomes of in vitro fertilization (IVF): a systematic literature review.Nutrition journal · 2022Pooled it
- Male cellular telephone exposure, fecundability, and semen quality: results from two preconception cohort studies.Human reproduction (Oxford, England) · 2021Pooled it
- Risk factors for inadequate response to ovarian stimulation in assisted reproduction cycles: systematic review.Journal of assisted reproduction and genetics · 2019Pooled it
- Lessons learned from longitudinal biomonitoring and birth cohort studies: informing the future of reproductive health research in Canada.Environmental health : a global access science source · 2026Article
- Relevance and challenges of exposome studies for environmental health research.Environmental health : a global access science source · 2026Review
- Exploratory assessment of preconception phthalate exposure on pregnancy and offspring health outcomes in mice.Journal of the Endocrine Society · 2026Article
- Environmental Chemicals as Modifiers of the Association between Age and Ovarian Reserve.medRxiv : the preprint server for health sciences · 2025Article
- Male partner pesticide residue exposure from fruit and vegetable intake in relation to outcomes of infertility treatment: a prospective cohort study.The American journal of clinical nutrition · 2025Article
- Article
- Association of urinary phthalate metabolite concentrations with inflammatory biomarker levels among pregnant women.Environmental research · 2025Article
- Urinary phthalates, serum omega-3 fatty acids and ovarian reserve among women seeking fertility treatment.International journal of hygiene and environmental health · 2025Article
- Pregnancy urinary phenol biomarker concentrations in relation to serum levels of inflammatory cytokines: Results from the EARTH study.Environment international · 2025Article
- Using mixture and exposome methods to assess the associations and interactions of chemical biomarkers with semen parameters.Environment international · 2025Article
- Phenol biomarker concentrations in human ovarian follicular fluid and the associations with in-vitro fertilization outcomes.International journal of hygiene and environmental health · 2025Article
- Effect Modification of Serum Omega-3 Fatty Acids on the Associations between Urinary Phthalate Biomarkers Mixture and Pregnancy Outcomes among Women Seeking Fertility Care.Environmental health perspectives · 2025Article
- Engaging, recruiting, and retaining pregnant people from marginalized communities in environmental health cohort studies: a scoping review.BMC public health · 2025Article
- Associations of Pesticide Residue Exposure from Fruit and Vegetable Intake with Ovarian Reserve.The Journal of nutrition · 2025Article
- Metabolic Mechanisms Underlying the Association Between the Profertility Diet and In Vitro Fertilization End Points.The Journal of nutrition · 2025Article
- Association of Glycemic Index, Glycemic Load, and Carbohydrate Intake with Antral Follicle Counts Among Subfertile Females.Nutrients · 2025Article
39 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
19 authors.
Funding
Abstract
backgroundThe Environment and Reproductive Health (EARTH) Study is an ongoing prospective preconception cohort designed to investigate the impact of environmental, nutritional, and lifestyle factors among both women and men on fertility and pregnancy outcomes.
methodsThe EARTH Study recruits women 18 to 45 years and men 18 to 55 years seeking fertility evaluation and treatment at the Massachusetts General Hospital (MGH) Fertility Center, Boston, USA. Women and men are eligible to join either independently or as a couple. Participants are followed from study entry throughout each fertility treatment cycle, once per trimester of pregnancy (for those achieving pregnancy), and up to labor and delivery, or until they discontinue treatment or withdraw from the study. The study collects biological samples, self-reported questionnaire data (including a food frequency questionnaire) and clinically abstracted information.
resultsAs of June 2017, the study cohort included 799 women and 487 men (447 couples; 40 men joined without female partners). Women were on average 34.7 years old at time of enrolment and predominantly Caucasian (81%), educated (49% have a graduate degree), and nulliparous (83%). Men were on average 36.6 years at baseline and mostly Caucasian (86%) and never-smokers (67%).
conclusionsThe EARTH Study is one of the few cohorts designed to examine multiple potentially critical windows of vulnerability, including the paternal and maternal preconception windows and the periconception and prenatal windows in pregnancy. It is also one of the few human studies that has assessed potential interactions between environmental exposures and dietary factors.
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