Evidence map›Paper›PMID 29888608›Full record

Trial reportIntegrative cancer therapies2018

Feasibility and Preliminary Efficacy of a 10-Week Resistance and Aerobic Exercise Intervention During Neoadjuvant Chemoradiation Treatment in Rectal Cancer Patients.

Favil Singh, Daniel A Galvão, Robert U Newton, Nigel A Spry, Michael K Baker, Dennis R Taaffe

Open access · goldAbstract readClinical TrialMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Integrative cancer therapies, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 7 pooled it
2.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 7 syntheses or guidelines pooled it, 48 citations in OpenAlex.

  1. Pooled it
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  3. Prehabilitation for patients undergoing neoadjuvant therapy prior to cancer resection: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
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  18. Prehabilitation in rectal surgery: a narrative review.International journal of colorectal disease · 2022
    Review
  19. High-intensity aerobic interval training and resistance training are feasible in rectal cancer patients undergoing chemoradiotherapy: a feasibility randomized controlled study.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Favil Singh1 Edith Cowan University, Perth, Western Australia, Australia.
Daniel A Galvão1 Edith Cowan University, Perth, Western Australia, Australia.
Robert U Newton1 Edith Cowan University, Perth, Western Australia, Australia.
Nigel A Spry1 Edith Cowan University, Perth, Western Australia, Australia.ORCID 0000-0001-8659-5065
Michael K Baker4 Australian Catholic University, New South Wales, Australia.
Dennis R Taaffe1 Edith Cowan University, Perth, Western Australia, Australia.
Edith Cowan University · AUAustralian Catholic University · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeoadjuvant chemoradiation treatment (CRT) in rectal cancer patients is associated with a reduction in physical capacity, lean mass and increased fatigue. As a countermeasure to these treatment-related adverse effects, we examined the feasibility and preliminary efficacy of a 10-week exercise program during CRT.

methodsTen rectal cancer patients (7 men, aged 27-70 years, body mass index = 26.4 ± 3.8 kg/m

resultsThere was a significant loss in appendicular skeletal muscle (-1.1 kg, P = .012), and fat mass (-0.8 kg, P = .029) following CRT. Despite the loss in skeletal muscle, leg press ( P = .030) and leg extension ( P = .046) strength improved by 27.2% and 22.7%, respectively, and leg press endurance by 76.7% ( P = .007). Changes in strength were accompanied by improved performance ( P < .05) in 6-m fast walking speed (6.9%) and dynamic balance as determined by the 6-m backwards walk (15.5%). There was minimal change in quality of life and fatigue, and no adverse events related to training.

conclusionsExercise during neoadjuvant CRT appears to be feasible and well tolerated in rectal cancer patients and may enhance physical function while minimizing adverse changes in body composition and cancer-related fatigue. These initial findings need to be confirmed in randomized controlled trials.

Indexed as

ChemoradiotherapyAdultAgedBody CompositionCombined Modality TherapyDigestive System Surgical ProceduresExerciseFatigueFeasibility StudiesFemaleHumansLegMaleMiddle AgedMuscle StrengthNeoadjuvant Therapychemoradiationcolorectal cancerexerciseprehabilitationpreoperativerectal cancer

Identifiers

PMID29888608
PMCPMC6142076
OpenAlexW2807889372

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.