ArticleOrganic letters2018
Directed, Palladium(II)-Catalyzed Intermolecular Aminohydroxylation of Alkenes Using a Mild Oxidation System.
Article in Organic letters, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Intermolecular Selective 1,2-Aminohydroxylation of 1,3-Dienes Enabled by Palladium/Copper/Oxygen Cooperation.Precision chemistry · 2026Article
- Catalytic Functionalization of Unactivated π-Bonds Enabled by Bidentate Directing Auxiliaries.Angewandte Chemie (International ed. in English) · 2026Review
- Synthesis of Antimicrobial Quinoline Derivatives Enabled by Synergistic Pd/Enamine Catalysis: Experimental and Computational Study.Precision chemistry · 2026Article
- Article
- Intramolecular Carboxyamidation of Alkyne-Tethered O-Acylhydroxamates through Formation of Fe(III)-Nitrenoids.Chemistry (Weinheim an der Bergstrasse, Germany) · 2024Article
- Mapping Ambiphile Reactivity Trends in the Anti-(Hetero)annulation of Non-Conjugated Alkenes via PdAngewandte Chemie (International ed. in English) · 2022Article
- Lewis Acid-Catalyzed Halonium Generation for Morpholine Synthesis and Claisen Rearrangement.The Journal of organic chemistry · 2022Article
- Modular synthesis of non-conjugatedTetrahedron · 2021Article
- Chiral Hypervalent Iodine Catalysis Enables an Unusual Regiodivergent Intermolecular Olefin Aminooxygenation.JACS Au · 2021Article
- Anti-selective [3+2] (Hetero)annulation of non-conjugated alkenes via directed nucleopalladation.Nature communications · 2020Article
- Development and Mechanistic Interrogation of Interrupted Chain-Walking in the Enantioselective Relay Heck Reaction.Journal of the American Chemical Society · 2020Article
- Transition-Metal-Catalyzed 1,2-Carboboration of Alkenes: Strategies, Mechanisms, and Stereocontrol.Israel journal of chemistry · 2020Article
- Palladium(0)-Catalyzed Directed syn-1,2-Carboboration and -Silylation: Alkene Scope, Applications in Dearomatization, and Stereocontrol by a Chiral Auxiliary.Angewandte Chemie (International ed. in English) · 2019Article
- Synthetic and Mechanistic Studies of a Versatile Heteroaryl Thioether Directing Group for Pd(II) Catalysis.ACS catalysis · 2019Article
- Ligand Controlled Ir-Catalyzed Regiodivergent Oxyamination of Unactivated Alkenes.Journal of the American Chemical Society · 2019Article
- A practical method for N-alkylation of phosphinic (thio)amides with alcohols via transfer hydrogenation.Tetrahedron · 2019Article
- Directed, Palladium(II)-Catalyzed Enantioselective anti-Carboboration of Alkenyl Carbonyl Compounds.ACS catalysis · 2019Article
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5 authors.
Funding
Abstract
A palladium(II)-catalyzed β,γ-aminohydroxylation reaction of nonconjugated alkenyl carbonyl compounds has been developed. This reaction utilizes a cleavable bidentate directing group to achieve regioselective aminopalladation. The resulting chelation-stabilized alkylpalladium(II) intermediate is then hydroxylated using oxygen/2,6-dimethylbenzoquinone in HFIP as the mild oxidation system. Under the optimized conditions, various nucleophiles and alkene substrates are capable of delivering good yields and high diastereoselectivities of the aminohydroxylated products.
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