ArticleDevelopmental medicine and child neurology2018
Sex chromosome trisomies are not associated with atypical lateralization for language.
Article in Developmental medicine and child neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Giftedness and atypical sexual differentiation: enhanced perceptual functioning through estrogen deficiency instead of androgen excess.Frontiers in endocrinology · 2024Review
- A cross-sectional study of early language abilities in children with sex chromosome trisomy (XXY, XXX, XYY) aged 1-6 years.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2022Article
- Autism and social anxiety in children with sex chromosome trisomies: an observational study.Wellcome open research · 2019Article
- Stage 1 Registered Report: Variation in neurodevelopmental outcomes in children with sex chromosome trisomies: protocol for a test of the double hit hypothesis.Wellcome open research · 2018Article
- Language phenotypes in children with sex chromosome trisomies.Wellcome open research · 2018Article
- Stage 2 Registered Report: Variation in neurodevelopmental outcomes in children with sex chromosome trisomies: testing the double hit hypothesis.Wellcome open research · 2018Article
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Abstract
aimTo test the hypothesis that sex chromosome trisomies (SCTs) are associated with reduced left lateralization for language.
methodUsing a cross-sectional design, language laterality was measured during an animation description task using functional transcranial Doppler ultrasonography. Data were available for 75 children with an SCT (47,XXX females [n=26], 47,XXY males [n=25], 47,XYY males [n=24]; mean age 11y 4mo [SD 3y 10mo]) and 132 comparison children with typical karyotypes (69 males, 63 females; mean age 9y 1mo [SD 1y 7mo]).
resultsLateralization for language did not differ between the SCT and comparison groups, either in mean laterality index or relative frequency of each laterality category. There were no differences when splitting the group with an SCT by trisomy. Handedness showed no group effects.
interpretationOur data provide no evidence for disrupted lateralization for language in SCTs. The brain basis of the cognitive phenotype in SCTs is unlikely to be a failure of the left hemisphere to specialize for language, as previously suggested. WHAT THIS PAPER ADDS: Children with a sex chromosome trisomy (SCT) have typically lateralized language. This disproves theories linking language problems to hemispheric specialization in SCTs.
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