Evidence map›Paper›PMID 29888335›Full record

ArticleAIMS biophysics2018

Single-molecule FRET reveals proofreading complexes in the large fragment of

Thomas V Christian, William H Konigsberg

Open access · goldAbstract read
In one paragraph

Article in AIMS biophysics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Thomas V ChristianKonigsberg Laboratory, Yale University, 333 Cedar Street, New Haven, CT 06520, USA.
William H KonigsbergKonigsberg Laboratory, Yale University, 333 Cedar Street, New Haven, CT 06520, USA.
Yale University · US

Funding

Molecular Biology and Structure of a DNA ReplicaseR01GM063276 · NIGMS · YALE UNIVERSITY · PI KONIGSBERG, WILLIAM H · 2001 to 2013
$4.2M
NIGMS NIH HHS R01 GM063276
6 · The paper itself

Abstract

There is increasing interest in the use of DNA polymerases (DNA pols) in next-generation sequencing strategies. These methodologies typically rely on members of the A and B family of DNA polymerases that are classified as high-fidelity DNA polymerases. These enzymes possess the ability to selectively incorporate the correct nucleotide opposite a templating base with an error frequency of only 1 in 10

Indexed as

base discriminationpol-exo switchingproof-readingsmFRET

Identifiers

PMID29888335
PMCPMC5990039
OpenAlexW2802807647

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.