ReviewNeurobiology of stress2018
Interactions between stress and physical activity on Alzheimer's disease pathology.
Review in Neurobiology of stress, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 37 citations in OpenAlex.
- The underlying mechanism of physical exercise on neurodegenerative diseases: the mediating role of psychological stress and resilience: a systematic review.Frontiers in psychology · 2025Pooled it
- [Effect of physical exercise on Alzheimer's disease. A sistematic review].Atencion primaria · 2020Pooled it
- Long-term voluntary exercise reveals limited translation of hippocampal molecular responses into neuroprotection in 5xFAD mice.bioRxiv : the preprint server for biology · 2026Article
- Insomnia symptoms and stress exposure interact in relation to Alzheimer's disease biomarkers.Journal of neurology · 2026Article
- The moderating role of walking in the association between HDL cholesterol and cognitive function among Korean older adults: a nationwide population-based cross-sectional study.Frontiers in public health · 2025Article
- Article
- Advancing Alzheimer's Therapeutics: Exploring the Impact of Physical Exercise in Animal Models and Patients.Cells · 2023Review
- The Impact of Sustained Ownership of a Pet on Cognitive Health: A Population-Based Study.Journal of aging and health · 2023Article
- Neuroprotective effects of resistance physical exercise on the APP/PS1 mouse model of Alzheimer's disease.Frontiers in neuroscience · 2023Article
- Associations between locus coeruleus MRI contrast and physiological responses to acute stress in younger and older adults.Brain research · 2022Article
- Relationship between university students' physical activity and mobile phone dependence: Mediating effect of subjective well-being and moderating effect of psychological capital.Frontiers in psychology · 2022Article
- Discovery of Investigational Drug CT1812, an Antagonist of the Sigma-2 Receptor Complex for Alzheimer's Disease.ACS medicinal chemistry letters · 2021Article
- Stress and Alzheimer's disease: A senescence link?Neuroscience and biobehavioral reviews · 2020Review
- Exercise Training Results in Lower Amyloid Plaque Load and Greater Cognitive Function in an Intensity Dependent Manner in the Tg2576 Mouse Model of Alzheimer's Disease.Brain sciences · 2020Article
- The Contribution of Physical Exercise to Brain Resilience.Frontiers in behavioral neuroscience · 2020Review
- Mast Cells in Stress, Pain, Blood-Brain Barrier, Neuroinflammation and Alzheimer's Disease.Frontiers in cellular neuroscience · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Physical activity and stress are both environmental modifiers of Alzheimer's disease (AD) risk. Animal studies of physical activity in AD models have largely reported positive results, however benefits are not always observed in either cognitive or pathological outcomes and inconsistencies among findings remain. Studies using forced exercise may increase stress and mitigate some of the benefit of physical activity in AD models, while voluntary exercise regimens may not achieve optimal intensity to provide robust benefit. We evaluated the findings of studies of voluntary and forced exercise regimens in AD mouse models to determine the influence of stress, or the intensity of exercise needed to outweigh the negative effects of stress on AD measures. In addition, we show that chronic physical activity in a mouse model of AD can prevent the effects of acute restraint stress on Aβ levels in the hippocampus. Stress and physical activity have many overlapping and divergent effects on the body and some of the possible mechanisms through which physical activity may protect against stress-induced risk factors for AD are discussed. While the physiological effects of acute stress and acute exercise overlap, chronic effects of physical activity appear to directly oppose the effects of chronic stress on risk factors for AD. Further study is needed to identify optimal parameters for intensity, duration and frequency of physical activity to counterbalance effects of stress on the development and progression of AD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.