Evidence map›Paper›PMID 29888310›Full record

ReviewNeurobiology of stress2018

Network-based approaches to examining stress in the adolescent brain.

Tiffany C Ho, Emily L Dennis, Paul M Thompson, Ian H Gotlib

Abstract readReview
In one paragraph

Review in Neurobiology of stress, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  3. Review
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  11. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Tiffany C HoDepartment of Psychology, Stanford University, USA.
Emily L DennisImaging Genetics Center, Mary and Mark Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, USA.
Paul M ThompsonImaging Genetics Center, Mary and Mark Stevens Institute for Neuroimaging and Informatics, Keck School of Medicine, University of Southern California, USA.
Ian H GotlibDepartment of Psychology, Stanford University, USA.

Funding

TR&D3: Intrinsic Surface MappingP41EB015922 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2012 to 2022
$14.1M
Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
The Effects of Early Life Stress on Neurodevelopment in Children and AdolescentsR01MH101495 · NIMH · STANFORD UNIVERSITY · PI GOTLIB, IAN H · 2013 to 2016
$2.9M
Alzheimer's disease risk analyzed using population imaging genomicsR01AG040060 · NIA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2011 to 2016
$2.5M
Predicting Brain Changes in HIV/AIDSR01NS080655 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI NAVIA, BRADFORD, THOMPSON, PAUL M · 2012 to 2015
$2.3M
Longitudinal Tracking of Traumatic Brain Injury: Advanced ConnectomicsK99NS096116 · NINDS · UNIVERSITY OF SOUTHERN CALIFORNIA · PI DENNIS, EMILY LARSEN · 2016 to 2017
$176k
NIA NIH HHS R01 AG040060NIBIB NIH HHS P41 EB015922NIBIB NIH HHS U54 EB020403NIMH NIH HHS R01 MH101495NINDS NIH HHS K99 NS096116NINDS NIH HHS R01 NS080655
6 · The paper itself

Abstract

Exposure to stress, particularly in periods of rapid brain maturation such as adolescence, can profoundly influence developmental processes that undergird the organization of structural and functional brain networks and that may mediate the association between stressful experiences and maladaptive outcomes. While studies in translational developmental neuroscience often focus on how specific brain regions or targeted connections are altered by stress and psychiatric disease, the emerging field of network science may be especially valuable for elucidating the impact of stress on the intricate connectomics of the adolescent brain. Here we review recent studies that use graph theory and other network science approaches to understand normative adolescent brain development, effects of childhood maltreatment on the brain, and disorders characterized by pathological responses to stress in adolescents. Overall, these studies demonstrate that graph theory can be useful in identifying and quantifying developmental processes related to segregation, integration, and localized hub influence that are affected by stress exposure and that may lead to psychopathology. Finally, we discuss limitations in the current application of graph theory in this area and suggest what we believe are important directions for future work.

Indexed as

AdolescentDepressionDiffusion tensor imagingGraph theoryResting-state functional magnetic resonance imagingStress

Identifiers

PMID29888310
PMCPMC5991327

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.