SynthesisJournal of immunology research2018
Meta-Analysis of the Changes of Peripheral Blood T Cell Subsets in Patients with Brucellosis.
Synthesis in Journal of immunology research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Mapping the research landscape of immune response in human brucellosis: a bibliometric analysis.Frontiers in microbiology · 2025Pooled it
- Prevalence, diagnosis, and manifestations of brucellosis: A systematic review and meta-analysis.Frontiers in veterinary science · 2022Pooled it
- CALLY Index and Inflammatory Parameters for Predicting Focal Involvement in Human Brucellosis: A Retrospective Cohort Study.Diagnostics (Basel, Switzerland) · 2026Article
- Development and validation of a serological marker-based nomogram for risk stratification of spinal brucellosis.Frontiers in cellular and infection microbiology · 2026Article
- Morphological remodeling of canine lymphocytes in Ehrlichia canis infection: quantitative analysis by scanning electron microscopy and fractal dimension.Revista brasileira de parasitologia veterinaria = Brazilian journal of veterinary parasitology : Orgao Oficial do Colegio Brasileiro de Parasitologia Veterinaria · 2026Article
- Comprehensive analysis of molecular immunological characteristics and potential biomarkers in brucellosis.Frontiers in immunology · 2026Article
- Immune cell and biochemical marker levels in the cerebrospinal fluid and blood of patients with brucella meningitis and their clinical significance.American journal of translational research · 2024Article
- Intracellular Growth Inhibition and Host Immune Modulation of 3-Amino-1,2,4-triazole in Murine Brucellosis.International journal of molecular sciences · 2023Article
- Presentation of severe brucellosis in 5-year-old boy - challenges and results.BMC infectious diseases · 2023Article
- Unravelling potential biomarkers for acute and chronic brucellosis through proteomic and bioinformatic approaches.Frontiers in cellular and infection microbiology · 2023Article
- Brucellosis complicated by myelofibrosis: report of five cases and review of literature.International journal of clinical and experimental pathology · 2023Article
- NLRP6 Induces Lung Injury and Inflammation Early in Brucella and Influenza Coinfection.Journal of personalized medicine · 2022Article
- Clinical characteristics and risk factors predictive of pulmonary embolism complicated in bronchiectasis patients: a retrospective study.BMC pulmonary medicine · 2022Article
- Key immunity characteristics of diverse stages of brucellosis in rural population from Inner Mongolia, China.Infectious diseases of poverty · 2022Article
- Facing the Human and Animal Brucellosis Conundrums: The Forgotten Lessons.Microorganisms · 2022Article
- The role of CXCR3 and its ligands expression in Brucellar spondylitis.BMC immunology · 2020Article
- Circulating Th1, Th2, Th17, Treg, and PD-1 Levels in Patients with Brucellosis.Journal of immunology research · 2019Article
- Clinical effect and safety evaluation of different dosage of Rituximab combined with Cyclophosphamide in treatment of refractory immune Thrombocytopenia.Pakistan journal of medical sciencesArticle
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brucellosis is one of the most prevalent zoonotic diseases in the world, but its pathogenesis is not very clear. At present, it is thought that it may be related to the immunity of T cells. The conclusions of related studies are inconsistent, and its clinical significance is not explicit. We searched published articles in electronic databases up to December 2017 identified as relating to the clinical features of human brucellosis in China. Only eight studies had sufficient quality for data extraction. Meta-analysis showed a significantly decreased proportion of CD4+ T cells in human brucellosis patients compared to healthy subject individuals. The frequency of CD8+ T cells was significantly higher in human brucellosis patients than that in the healthy control group. The pooled analysis presented a significant decrease of the CD4+/CD8+ ratio in human brucellosis patients compared to healthy subjects. There is immunologic dysfunction of T lymphocyte in patients with human brucellosis, the CD4+ and CD8+ T cells might be the important factors affecting the progress of brucellosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.