Evidence map›Paper›PMID 29888271›Full record

ArticleBioMed research international2018

Purification and Characterization of Antibodies in Single-Chain Format against the E6 Oncoprotein of Human Papillomavirus Type 16.

F Verachi, Z Percario, P Di Bonito, E Affabris, C Amici, L Accardi

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
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  4. Review
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

F VerachiDepartment of Biology, University of Rome Tor Vergata, Rome, Italy.
Z PercarioDepartment of Science, Roma Tre University, Rome, Italy.
P Di BonitoDepartment of Infectious Diseases, Italian National Institute of Health, Rome, Italy.
E AffabrisDepartment of Science, Roma Tre University, Rome, Italy.
C AmiciDepartment of Biology, University of Rome Tor Vergata, Rome, Italy.
L AccardiDepartment of Infectious Diseases, Italian National Institute of Health, Rome, Italy.ORCID 0000-0002-5091-9272
Roma Tre University · ITUniversity of Rome Tor Vergata · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In Human Papillomaviruses- (HPV-) associated carcinogenesis, continuous expression of the E6 oncoprotein supports its value as a potential target for the development of diagnostics and therapeutics for HPV cancer. We previously reported that the I7 single-chain antibody fragment (scFv) specific for HPV16 E6, expressed as an intrabody by retroviral system, could inhibit significantly the growth of cervical cancer cells

Indexed as

CarcinogenesisCell Line, TumorFemaleHuman papillomavirus 16HumansOncogene Proteins, ViralPapillomavirus InfectionsRepressor ProteinsSingle-Chain AntibodiesUterine Cervical NeoplasmsE6 protein, Human papillomavirus type 16Oncogene Proteins, ViralRepressor ProteinsSingle-Chain Antibodies

Identifiers

PMID29888271
PMCPMC5985123
OpenAlexW2803599833

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.