ArticleAmerican journal of translational research2018
Long non-coding RNA RNCR3 promotes prostate cancer progression through targeting miR-185-5p.
Article in American journal of translational research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 60 citations in OpenAlex.
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Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long non-coding RNAs (lncRNAs) have been suggested to play important roles in the development of numerous kinds of human cancers. Increasing data has indicated that lncRNA RNCR3 has been involved in some human diseases. However, the exactly biological function and potential mechanisms of RNCR3 in the development of prostate cancer is still unclear. Here, our results confirmed that the RNCR3 expression was increased in prostate cancer compared to the corresponding adjacent normal prostate tissues. Moreover, our data showed that the increased expression of RNCR3 is significantly associated with tumor progression and poor survival of prostate cancer patients. Additionally, we found that RNCR3 knockdown could suppress the ability of proliferation, colony formation, and invasion of prostate cancer cells. Finally, we further confirmed that RNCR3 binds to miR-185-5p, which has been identified as a tumor suppressor in some human cancers, including prostate cancer. We also confirmed that the oncogenic function of RNCR3 in prostate cancer are partly mediated by negative regulation of miR-185-5p targeted BRD8 ISO2. Our data revealed that RNCR3 functions as an tumor-promoting lncRNA in prostate cancer and may serve as a novel important biomarker for the diagnosis and treatment of prostate cancer.
Indexed as
Identifiers
29887969PMC5992541W3021943911What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.